Quantifying Uncertainty in a Risk Assessment Using Human Data

William E. Fayerweather, James J. Collins, A. Robert Schnatter, F. Terry Hearne, Reo A. Menning and Daniel P. Reynefr

Risk Analysis, 1999, vol. 19, issue 6, 1077-1090

Abstract: A call for risk assessment approaches that better characterize and quantify uncertainty has been made by the scientific and regulatory community. This paper responds to that call by demonstrating a distributional approachthat draws upon human data to derive potency estimates and to identify and quantify important sources of uncertainty. The approach is rooted in the science of decision analysis and employs an influence diagram, a decision tree, probabilistic weights, and a distribution of point estimates of carcinogenic potency. Its results estimate the likelihood of different carcinogenicrisks (potencies) for a chemical under a specific scenario. For this exercise, human data on formaldehyde were employed to demonstrate the approach. Sensitivity analyses were performed to determine the relative impact of specific levels and alternatives on the potency distribution. The resulting potency estimates are compared with the results of an exercise using animal data on formaldehyde. The paper demonstrates that distributional risk assessment is readily adapted to situations in which epidemiologic data serve as the basis for potency estimates. Strengths and weaknesses of the distributional approach are discussed. Areas for further application and research are recommended.

Date: 1999
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Citations: View citations in EconPapers (4)

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https://doi.org/10.1111/j.1539-6924.1999.tb01129.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:19:y:1999:i:6:p:1077-1090

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