Multistage Model Interpretation of Additive and Multiplicative Carcinogenic Effects

Herman J. Gibb and Chao W. Chen

Risk Analysis, 1986, vol. 6, issue 2, 167-170

Abstract: Under the assumption of multistage carcinogenesis, a multiplicative carcinogenic effect would be produced by the action of different carcinogens in a mixture on different stages of the carcinogenic process. An additive effect would be produced by the effect of different carcinogens on the same stage. A mathematical argument for these hypotheses is presented here.

Date: 1986
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https://doi.org/10.1111/j.1539-6924.1986.tb00204.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:6:y:1986:i:2:p:167-170

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