Noise in gene expression may be a choice of cellular system

Rajesh Karmakar ()
Additional contact information
Rajesh Karmakar: Ramakrishna Mission Vidyamandira, Belur Math, Howrah 711202, West Bengal, India

International Journal of Modern Physics C (IJMPC), 2019, vol. 30, issue 02n03, 1-17

Abstract: Gene expression and its regulation is a nonequilibrium stochastic process. Different molecules are involved in several biochemical steps in this process with low copies. It is observed that the stochasticity in biochemical processes is mainly due to the low copy number of the molecules present in the system. Several studies also show that the nonequilibrium biochemical processes require energy cost. But cellular system has developed itself through natural evolution by minimizing energy cost for optimum output. Here, we study the role of stochasticity qualitatively in a network of two genes using stochastic simulation method and approximately measure the energy consumption for the gene expression process. We find that the noise in gene expression process reduces the energy cost of protein synthesis. Therefore, we argued that the stochasticity in gene expression may be a choice of cellular system for protein synthesis with minimum energy cost.

Keywords: Gene expression and regulation; nonequilibrium biochemical processes; stochastic simulation (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.worldscientific.com/doi/abs/10.1142/S0129183119500141
Access to full text is restricted to subscribers

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wsi:ijmpcx:v:30:y:2019:i:02n03:n:s0129183119500141

Ordering information: This journal article can be ordered from

DOI: 10.1142/S0129183119500141

Access Statistics for this article

International Journal of Modern Physics C (IJMPC) is currently edited by H. J. Herrmann

More articles in International Journal of Modern Physics C (IJMPC) from World Scientific Publishing Co. Pte. Ltd.
Bibliographic data for series maintained by Tai Tone Lim ().