Well-being differences and changes in people with somatic and psychiatric disorders or multimorbidities: modelling COVID-19 as a global natural experiment of stress vulnerability

Till J Adam, Trevor Thompson, Fabiola H Peroz, Jan P. Heisig, Paul Gellert, Enrique Alonso-Perez, Lara Bister, Lau Caspar Thygesen, Philippe Conus, Roland von Känel, Soraya Seedat, Denisa Manková, Daniel Guinart, Eduard Vieta, Mark J Millan, Diego De Leo, Michael Berk, Jess Fiedorowicz, Lin Yang, Jari Tiihonen, Harald Aschauer, Monika Schlögelhofer, Jane E Hamilton, Marco Solmi and Christoph U. Correll

EconStor Open Access Articles and Book Chapters, 2026, vol. 29, issue 1, No e302777, 13 pages

Abstract: Somatic and psychiatric illnesses and multimorbidities increase stress-vulnerability and decrease well-being. We aimed to identify high-risk disorder profiles for lower well-being and well-being decline under stress, modelling COVID-19 as a natural experiment. The global Collaborative Outcomes Study on Health and Functioning during Infection Times survey assessed the World Health Organization-Five Well-being Index (WHO-5) (0-100) retrospectively pre-pandemic and intra-pandemically. Mixed-effects models, controlling for demographic/pandemic-related covariates, examined coprimary outcomes: total pre-pandemic WHO-5 and pre-to-intra-pandemic change (estimating β); pre-pandemic WHO-5

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:zbw:espost:343490

DOI: 10.1136/bmjment-2026-302777

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