A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

Daniele Canzio, Maofu Liao, Nariman Naber, Edward Pate, Adam Larson, Shenping Wu, Diana B. Marina, Jennifer F. Garcia, Hiten D. Madhani, Roger Cooke, Peter Schuck, Yifan Cheng and Geeta J. Narlikar ()
Additional contact information
Daniele Canzio: University of California San Francisco
Maofu Liao: University of California San Francisco
Nariman Naber: University of California San Francisco
Edward Pate: Voiland School of Chemical Engineering and Bioengineering, Washington State University
Adam Larson: University of California San Francisco
Shenping Wu: University of California San Francisco
Diana B. Marina: University of California San Francisco
Jennifer F. Garcia: University of California San Francisco
Hiten D. Madhani: University of California San Francisco
Peter Schuck: National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Yifan Cheng: University of California San Francisco
Geeta J. Narlikar: University of California San Francisco

Nature, 2013, vol. 496, issue 7445, 377-381

Abstract: The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin assembly and gene silencing.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature12032 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:496:y:2013:i:7445:d:10.1038_nature12032

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12032

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().