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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

Jiaquan Liu, Jeungphill Hanne, Brooke M. Britton, Jared Bennett, Daehyung Kim, Jong-Bong Lee () and Richard Fishel ()
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Jiaquan Liu: The Ohio State University Wexner Medical Center
Jeungphill Hanne: The Ohio State University Wexner Medical Center
Brooke M. Britton: The Ohio State University Wexner Medical Center
Jared Bennett: The Ohio State University Wexner Medical Center
Daehyung Kim: Pohang University of Science and Technology (POSTECH)
Jong-Bong Lee: Pohang University of Science and Technology (POSTECH)
Richard Fishel: The Ohio State University Wexner Medical Center

Nature, 2016, vol. 539, issue 7630, 583-587

Abstract: MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate one-dimensional diffusion along the DNA and, with MutH, facilitate the search for a distant excision initiation site.

Date: 2016
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DOI: 10.1038/nature20562

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