Statistics in Biosciences

2016 - 2025

Current editor(s): Hongyu Zhao and Xihong Lin

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Springer
International Chinese Statistical Association
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Volume 15, issue 3, 2023

Introduction to Special Issue on Machine Learning Algorithms in Genomics and Genetics pp. 541-544

Yingying Wei

Estimating Heterogeneous Treatment Effect on Multivariate Responses Using Random Forests pp. 545-561

Boyi Guo, Hannah D. Holscher, Loretta S. Auvil, Michael E. Welge, Colleen B. Bushell, Janet A. Novotny, David J. Baer, Nicholas A. Burd, Naiman A. Khan and Ruoqing Zhu

Integrative Structural Learning of Mixed Graphical Models via Pseudo-likelihood pp. 562-582

Qingyang Liu and Yuping Zhang

Simultaneous Learning the Dimension and Parameter of a Statistical Model with Big Data pp. 583-607

Long Wang, Fangzheng Xie and Yanxun Xu

Nonnegative Matrix Factorization with Group and Basis Restrictions pp. 608-632

Phillip Shreeves, Jeffrey L. Andrews, Xinchen Deng, Ramie Ali-Adeeb and Andrew Jirasek

scPI: A Scalable Framework for Probabilistic Inference in Single-Cell RNA-Sequencing Data Analysis pp. 633-656

Jingsi Ming, Jia Zhao and Can Yang

An Artificial Intelligence Approach for Gene Editing Off-Target Quantification: Convolutional Self-attention Neural Network Designs and Considerations pp. 657-668

Jiecong Lin, Xingjian Chen and Ka-Chun Wong

A Unified Bayesian Framework for Bi-overlapping-Clustering Multi-omics Data via Sparse Matrix Factorization pp. 669-691

Fangting Zhou, Kejun He, James J. Cai, Laurie A. Davidson, Robert S. Chapkin and Yang Ni

Detection of Cell Separation-Induced Gene Expression Through a Penalized Deconvolution Approach pp. 692-718

An-Shun Tai, Chun-Chao Wang and Wen-Ping Hsieh

Bayesian Joint Modeling of Single-Cell Expression Data and Bulk Spatial Transcriptomic Data pp. 719-733

Jinge Yu, Qiuyu Wu and Xiangyu Luo

Unlocking Cellular Insights Through Cell-Type Decomposition pp. 734-736

Xiaoyu Song

AI-Powered Bayesian Statistics in Biomedicine pp. 737-749

Qiwei Li

Volume 15, issue 2, 2023

Longitudinal Associations Between Timing of Physical Activity Accumulation and Health: Application of Functional Data Methods pp. 309-329

Wenyi Lin, Jingjing Zou, Chongzhi Di, Dorothy D. Sears, Cheryl L. Rock and Loki Natarajan

Properties of the Estimators of the Cox Regression Model with Imputed Data pp. 330-352

Luciana Carla Chiapella, Marta Beatriz Quaglino and María Eugenia Mamprin

Evaluating Dynamic Discrimination Performance of Risk Prediction Models for Survival Outcomes pp. 353-371

Jing Zhang, Jing Ning and Ruosha Li

Simultaneous Confidence Band Approach for Comparison of COVID-19 Case Counts pp. 372-383

Q. Shao

On the Methodological Aspects of the Clinical Trials for COVID-19 Conducted in the First Year of the Pandemic: A Descriptive Analysis pp. 384-396

Eleni Georgiadi and Athanasios Sachlas

Bayesian Index Models for Heterogeneous Treatment Effects on a Binary Outcome pp. 397-418

Hyung G. Park, Danni Wu, Eva Petkova, Thaddeus Tarpey and R. Todd Ogden

A Non-parametric Test Based on Local Pairwise Comparisons of Patients for Single and Composite Endpoints pp. 419-429

Xuan Ye and Heng Li

Analysis of the Cox Model with Longitudinal Covariates with Measurement Errors and Partly Interval Censored Failure Times, with Application to an AIDS Clinical Trial pp. 430-454

Yanqing Sun, Qingning Zhou and Peter B. Gilbert

Semiparametric Trend Analysis for Stratified Recurrent Gap Times Under Weak Comparability Constraint pp. 455-474

Peng Liu, Yijian Huang, Kwun Chuen Gary Chan and Ying Qing Chen

Clinical Trial Design—What is the Critical Question for Decision-Making? pp. 475-489

Jingjing Ye, Hong Tian, Xiang Tony Guo and Naitee Ting

Bayesian Analysis of Multivariate Matched Proportions with Sparse Response pp. 490-509

Mark J. Meyer, Haobo Cheng and Katherine Hobbs Knutson

Evaluation of Designs and Estimation Methods Under Response-Dependent Two-Phase Sampling for Genetic Association Studies pp. 510-539

Brady Ryan, Ananthika Nirmalkanna, Candemir Cigsar and Yildiz E. Yilmaz

Volume 15, issue 1, 2023

New Confidence Intervals for Relative Risk of Two Correlated Proportions pp. 1-30

Natalie DelRocco, Yipeng Wang, Dongyuan Wu, Yuting Yang and Guogen Shan

Impact of the Error Structure on the Design and Analysis of Enzyme Kinetic Models pp. 31-56

Elham Yousefi and Werner Müller

Using Controlled Feeding Study for Biomarker Development in Regression Calibration for Disease Association Estimation pp. 57-113

Cheng Zheng, Yiwen Zhang, Ying Huang and Ross Prentice

Bayesian Framework for Causal Inference with Principal Stratification and Clusters pp. 114-140

Li He, Yu-Bo Wang, William C. Bridges, Zhulin He and S. Megan Che

Irregular Shaped Small Nodule Detection Using a Robust Scan Statistic pp. 141-162

Ali Abolhassani, Marcos O. Prates and Safieh Mahmoodi

A Step-Wise Multiple Testing for Linear Regression Models with Application to the Study of Resting Energy Expenditure pp. 163-192

Junyi Zhang, Zimian Wang, Zhezhen Jin and Zhiliang Ying

A New Algorithm for Convex Biclustering and Its Extension to the Compositional Data pp. 193-216

Binhuan Wang, Lanqiu Yao, Jiyuan Hu and Huilin Li

Semiparametric Density Ratio Model for Survival Data with a Cure Fraction pp. 217-241

Weibin Zhong and Guoqing Diao

On High-Dimensional Covariate Adjustment for Estimating Causal Effects in Randomized Trials with Survival Outcomes pp. 242-260

Ran Dai, Cheng Zheng and Mei-Jie Zhang

A Functional Model for Studying Common Trends Across Trial Time in Eye Tracking Experiments pp. 261-287

Mingfei Dong, Donatello Telesca, Catherine Sugar, Frederick Shic, Adam Naples, Scott P. Johnson, Beibin Li, Adham Atyabi, Minhang Xie, Sara J. Webb, Shafali Jeste, Susan Faja, April R. Levin, Geraldine Dawson, James C. McPartland and Damla Şentürk

A Perception-Augmented Hidden Markov Model for Parent–Child Relations in Families of Youth with Type 1 Diabetes pp. 288-308

Ruijin Lu, Tonja R. Nansel and Zhen Chen

Volume 14, issue 3, 2022

A Weighted Sample Framework to Incorporate External Calculators for Risk Modeling pp. 363-379

Debashis Ghosh and Michael S. Sabel

A New Bayesian Two-Sample t Test and Solution to the Behrens–Fisher Problem Based on Gaussian Mixture Modelling with Known Allocations pp. 380-412

Riko Kelter

Efficacy-Driven Dose Finding with Toxicity Control in Phase I Oncology Studies pp. 413-431

Qingyang Liu, Junxian Geng, Frank Fleischer and Qiqi Deng

High-Dimensional Mediation Analysis with Applications to Causal Gene Identification pp. 432-451

Qi Zhang

A Model-Based Approach to Assess Epidemic Risk pp. 452-484

Hugo Dolan and Riccardo Rastelli

Characterizing Spatiotemporal Transcriptome of the Human Brain Via Low-Rank Tensor Decomposition pp. 485-513

Tianqi Liu, Ming Yuan and Hongyu Zhao

Epistasis Detection via the Joint Cumulant pp. 514-532

Randall Reese, Guifang Fu, Geran Zhao, Xiaotian Dai, Xiaotian Li and Kenneth Chiu

Fast Multivariate Probit Estimation via a Two-Stage Composite Likelihood pp. 533-549

Bryan Ting, Fred Wright and Yi-Hui Zhou

Estimation of the Proportional Mean Residual Life Model with Internal and Longitudinal Covariates pp. 550-563

Ruiwen Zhou and Jianguo Sun

Targeted Search for Individualized Clinical Decision Rules to Optimize Clinical Outcomes pp. 564-581

Yanqing Wang, Yingqi Zhao and Yingye Zheng

A Generalized Interrupted Time Series Model for Assessing Complex Health Care Interventions pp. 582-610

Maricela Cruz, Hernando Ombao and Daniel L. Gillen

Volume 14, issue 2, 2022

Introduction to Special Issue on Leveraging External Data to Improve Trial Efficiency pp. 193-196

Lanju Zhang and Naitee Ting

Flexible Conditional Borrowing Approaches for Leveraging Historical Data in the Bayesian Design of Superiority Trials pp. 197-215

Wenlin Yuan, Ming-Hui Chen and John Zhong

A Simple Approach to Incorporating Historical Control Data in Clinical Trial Design and Analysis pp. 216-236

Lanju Zhang, Zailong Wang, Li Wang, Lu Cui, Jeremy Sokolove and Ivan Chan

Leveraging Natural History Data in One- and Two-Arm Hierarchical Bayesian Studies of Rare Disease Progression pp. 237-258

Arnaud Monseur, Bradley P. Carlin, Bruno Boulanger, Andreea Seferian, Laurent Servais, Chris Freitag and Leen Thielemans

A Simulation-Based Evaluation of Statistical Methods for Hybrid Real-World Control Arms in Clinical Trials pp. 259-284

Mingyang Shan, Douglas Faries, Andy Dang, Xiang Zhang, Zhanglin Cui and Kristin M. Sheffield

Building an External Control Arm for Development of a New Molecular Entity: An Application in a Recurrent Glioblastoma Trial for MDNA55 pp. 285-303

Antara Majumdar, Ruthanna Davi, Martin Bexon, Chandtip Chandhasin, Melissa Coello, Fahar Merchant and Nina Merchant

Clinical Trials with External Control: Beyond Propensity Score Matching pp. 304-317

Hongwei Wang, Yixin Fang, Weili He, Ruizhe Chen and Su Chen

A Power Prior Approach for Leveraging External Longitudinal and Competing Risks Survival Data Within the Joint Modeling Framework pp. 318-336

Md. Tuhin Sheikh, Ming-Hui Chen, Jonathan A. Gelfond and Joseph G. Ibrahim

Improving Early Futility Determination by Learning from External Data in Pediatric Cancer Clinical Trials pp. 337-351

Jingjing Ye and Gregory Reaman

Optimal Biomarker Cutoff Identification and Validation pp. 352-362

Jianan Hui and Wenchuan Guo

Volume 14, issue 1, 2022

Discriminatory Capacity of Prenatal Ultrasound Measures for Large-for-Gestational-Age Birth: A Bayesian Approach to ROC Analysis Using Placement Values pp. 1-22

Soutik Ghosal and Zhen Chen

Using Copulas for Bayesian Meta-analysis pp. 23-41

Savita Jain, Suresh K. Sharma and Kanchan Jain

Correlated Positive Stable Frailty Models Based on Reversed Hazard Rate pp. 42-65

David D. Hanagal

Exposure Adjusted Incidence Rate and Event Rate in Clinical Trials with Treatment Crossover pp. 66-78

Yunxia Sui, Ruofei Zhao, Yihan Li and Xin Wang

Augmenting Both Arms of a Randomized Controlled Trial Using External Data: An Application of the Propensity Score-Integrated Approaches pp. 79-89

Heng Li, Wei-Chen Chen, Chenguang Wang, Nelson Lu, Changhong Song, Ram Tiwari, Yunling Xu and Lilly Q. Yue

Sample Size Re-estimation with the Com-Nougue Method to Evaluate Treatment Effect pp. 90-103

Jin Wang

Correction to: Sample Size Re-estimation with the Com-Nougue Method to Evaluate Treatment Effect pp. 104-104

Jin Wang

Estimation of Discrete Survival Function through Modeling Diagnostic Accuracy for Mismeasured Outcome Data pp. 105-138

Hee-Koung Joeng, Abidemi K. Adeniji, Naitee Ting and Ming-Hui Chen

Assessments of Conditional and Unconditional Type I Error Probabilities for Bayesian Hypothesis Testing with Historical Data Borrowing pp. 139-157

Hui Quan, Xiaofei Chen, Xun Chen and Xiaodong Luo

Optimal and/or Efficient Cross-Over Designs Balanced for Carry-Over of Active Treatments pp. 158-174

Jigneshkumar Gondaliya and Jyoti Divecha

Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times pp. 175-190

Yasin Khadem Charvadeh, Grace Y. Yi, Yuan Bian and Wenqing He

Correction to: Is 14-Days a Sensible Quarantine Length for COVID-19? Examinations of Some Associated Issues with a Case Study of COVID-19 Incubation Times pp. 191-191

Yasin Khadem Charvadeh, Grace Y. Yi, Yuan Bian and Wenqing He