PLOS Biology

2003 - 2025

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Volume 18, issue 12, 2020

Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx–dependent pyroptosis in intestinal epithelial cells pp. 1-31

Qiyun Zhong, Theodoros I Roumeliotis, Zuza Kozik, Massiel Cepeda-Molero, Luis Ángel Fernández, Avinash R Shenoy, Chris Bakal, Gad Frankel and Jyoti S Choudhary

The actions of others act as a pseudo-reward to drive imitation in the context of social reinforcement learning pp. 1-25

Anis Najar, Emmanuelle Bonnet, Bahador Bahrami and Stefano Palminteri

Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism pp. 1-25

Albert Zhang, Ziqiang Guan, Kyle Ockerman, Pengyuan Dong, Jiansheng Guo, Zhiping Wang and Dong Yan

Patterns of smallpox mortality in London, England, over three centuries pp. 1-27

Olga Krylova and David J D Earn

LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient pp. 1-35

Jongbo Lee, Jumin Park, Ji-hyung Kim, Giwook Lee, Tae-Eun Park, Ki-Jun Yoon, Yoon Ki Kim and Chunghun Lim

Ensuring the quality and specificity of preregistrations pp. 1-18

Marjan Bakker, Coosje L S Veldkamp, Marcel A L M van Assen, Elise A V Crompvoets, How Hwee Ong, Brian A Nosek, Courtney K Soderberg, David Mellor and Jelte M Wicherts

Generalizable brain network markers of major depressive disorder across multiple imaging sites pp. 1-26

Ayumu Yamashita, Yuki Sakai, Takashi Yamada, Noriaki Yahata, Akira Kunimatsu, Naohiro Okada, Takashi Itahashi, Ryuichiro Hashimoto, Hiroto Mizuta, Naho Ichikawa, Masahiro Takamura, Go Okada, Hirotaka Yamagata, Kenichiro Harada, Koji Matsuo, Saori C Tanaka, Mitsuo Kawato, Kiyoto Kasai, Nobumasa Kato, Hidehiko Takahashi, Yasumasa Okamoto, Okito Yamashita and Hiroshi Imamizu

Volume 18, issue 11, 2020

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis pp. 1-24

Manon Gervais, Gwenaël Labouèbe, Alexandre Picard, Bernard Thorens and Sophie Croizier

Many, but not all, lineage-specific genes can be explained by homology detection failure pp. 1-24

Caroline M Weisman, Andrew W Murray and Sean R Eddy

We need to keep a reproducible trace of facts, predictions, and hypotheses from gene to function in the era of big data pp. 1-10

Simon Kasif and Richard J Roberts

Rules warp feature encoding in decision-making circuits pp. 1-38

R Becket Ebitz, Jiaxin Cindy Tu and Benjamin Y Hayden

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype pp. 1-25

Mahmoud H Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M H Schiffers, Ger M Janssen, Pamela W M Kleikers, Anil Wipat, Jan Baumbach, Jo G R De Mey and Harald H H W Schmidt

Volume 18, issue 10, 2020

The COVID-19 response illustrates that traditional academic reward structures and metrics do not reflect crucial contributions to modern science pp. 1-3

Adam J Kucharski, Sebastian Funk and Rosalind M Eggo

Updated science-wide author databases of standardized citation indicators pp. 1-3

John P A Ioannidis, Kevin W Boyack and Jeroen Baas

Optimising risk-based surveillance for early detection of invasive plant pathogens pp. 1-25

Alexander J Mastin, Timothy R Gottwald, Frank van den Bosch, Nik J Cunniffe and Stephen Parnell

Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia–thalamic communication pp. 1-38

Bettina C Schwab, Daisuke Kase, Andrew Zimnik, Robert Rosenbaum, Marcello G Codianni, Jonathan E Rubin and Robert S Turner

Volume 18, issue 9, 2020

Evolutionary dynamics in the Anthropocene: Life history and intensity of human contact shape antipredator responses pp. 1-17

Benjamin Geffroy, Bastien Sadoul, Breanna J Putman, Oded Berger-Tal, László Zsolt Garamszegi, Anders Pape Møller and Daniel T Blumstein

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies pp. 1-37

Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T. Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan S Shaw, Eric K Moses, Dianna J Magliano and Peter J Meikle

Volume 18, issue 8, 2020

Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us pp. 1-6

Carolyn Coyne, Jimmy D Ballard and Ira J Blader

The right temporoparietal junction enables delay of gratification by allowing decision makers to focus on future events pp. 1-20

Alexander Soutschek, Marius Moisa, Christian C Ruff and Philippe N Tobler

Volume 18, issue 7, 2020

Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma pp. 1-17

Shoya Iwanami, Kosaku Kitagawa, Hirofumi Ohashi, Yusuke Asai, Kaho Shionoya, Wakana Saso, Kazane Nishioka, Hisashi Inaba, Shinji Nakaoka, Takaji Wakita, Odo Diekmann, Shingo Iwami and Koichi Watashi

The Hong Kong Principles for assessing researchers: Fostering research integrity pp. 1-14

David Moher, Lex Bouter, Sabine Kleinert, Paul Glasziou, Mai Har Sham, Virginia Barbour, Anne-Marie Coriat, Nicole Foeger and Ulrich Dirnagl

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research pp. 1-12

Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T Holgate, David W Howells, Natasha A Karp, Stanley E Lazic, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole H Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler and Hanno Würbel

Volume 18, issue 6, 2020

Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion pp. 1-31

Salim T Islam, Israel Vergara Alvarez, Fares Saïdi, Annick Guiseppi, Evgeny Vinogradov, Gaurav Sharma, Leon Espinosa, Castrese Morrone, Gael Brasseur, Jean-François Guillemot, Anaïs Benarouche, Jean-Luc Bridot, Gokulakrishnan Ravicoularamin, Alain Cagna, Charles Gauthier, Mitchell Singer, Henri-Pierre Fierobe, Tâm Mignot and Emilia M F Mauriello

Volume 18, issue 5, 2020

Dynamical footprints enable detection of disease emergence pp. 1-20

Tobias S Brett and Pejman Rohani

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations pp. 1-20

Elsa Hansen, Jason Karslake, Robert J Woods, Andrew F Read and Kevin B Wood

Volume 18, issue 3, 2020

Eco-evolutionary significance of “loners” pp. 1-27

Fernando W Rossine, Ricardo Martinez-Garcia, Allyson E Sgro, Thomas Gregor and Corina E Tarnita

Context effects on probability estimation pp. 1-45

Wei-Hsiang Lin, Justin L Gardner and Shih-Wei Wu

Interactive youth science workshops benefit student participants and graduate student mentors pp. 1-10

Pallavi Kompella, Brant Gracia, Lucy LeBlanc, Shelly Engelman, Chinmayee Kulkarni, Niral Desai, Viviana June, Stephen March, Sarah Pattengale, Gabriel Rodriguez-Rivera, Seung Woo Ryu, Isabel Strohkendl, Pooja Mandke and Greg Clark

Bacterially produced metabolites protect C. elegans neurons from degeneration pp. 1-31

Arles Urrutia, Víctor A García-Angulo, Andrés Fuentes, Mauricio Caneo, Marcela Legüe, Sebastián Urquiza, Scarlett E Delgado, Juan Ugalde, Paula Burdisso and Andrea Calixto

Volume 18, issue 2, 2020

Macroalgal germplasm banking for conservation, food security, and industry pp. 1-10

Rachael Wade, Simona Augyte, Maddelyn Harden, Sergey Nuzhdin, Charles Yarish and Filipe Alberto

Volume 18, issue 1, 2020

PlotTwist: A web app for plotting and annotating continuous data pp. 1-10

Joachim Goedhart

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity pp. 1-28

Courtney A Lovejoy, Kaori Takai, Michael S Huh, David J Picketts and Titia de Lange

Volume 17, issue 12, 2019

Coinfections by noninteracting pathogens are not independent and require new tests of interaction pp. 1-25

Frédéric M Hamelin, Linda J S Allen, Vrushali A Bokil, Louis J Gross, Frank M Hilker, Michael J Jeger, Carrie A Manore, Alison G Power, Megan A Rúa and Nik J Cunniffe

High-order interactions distort the functional landscape of microbial consortia pp. 1-34

Alicia Sanchez-Gorostiaga, Djordje Bajić, Melisa L Osborne, Juan F Poyatos and Alvaro Sanchez

Volume 17, issue 11, 2019

All or nothing: No half-Merge and the evolution of syntax pp. 1-5

Robert C Berwick and Noam Chomsky

Development, environmental degradation, and disease spread in the Brazilian Amazon pp. 1-8

Marcia C Castro, Andres Baeza, Cláudia Torres Codeço, Zulma M Cucunubá, Ana Paula Dal’Asta, Giulio A De Leo, Andrew P Dobson, Gabriel Carrasco-Escobar, Raquel Martins Lana, Rachel Lowe, Antonio Miguel Vieira Monteiro, Mercedes Pascual and Mauricio Santos-Vega

Neuroimaging-based prediction of mental traits: Road to utopia or Orwell? pp. 1-6

Simon B Eickhoff and Robert Langner

Data-driven analyses of motor impairments in animal models of neurological disorders pp. 1-30

Hardeep Ryait, Edgar Bermudez-Contreras, Matthew Harvey, Jamshid Faraji, Behroo Mirza Agha, Andrea Gomez-Palacio Schjetnan, Aaron Gruber, Jon Doan, Majid Mohajerani, Gerlinde A S Metz, Ian Q Whishaw and Artur Luczak

Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias pp. 1-15

Shir Mandelboum, Zohar Manber, Orna Elroy-Stein and Ran Elkon

Volume 17, issue 10, 2019

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance pp. 1-34

Jeff Maltas and Kevin B Wood

Refining animal research: The Animal Study Registry pp. 1-12

Bettina Bert, Céline Heinl, Justyna Chmielewska, Franziska Schwarz, Barbara Grune, Andreas Hensel, Matthias Greiner and Gilbert Schönfelder

Predicting translational progress in biomedical research pp. 1-25

B Ian Hutchins, Matthew T Davis, Rebecca A Meseroll and George M Santangelo

A neural ensemble correlation code for sound category identification pp. 1-41

Mina Sadeghi, Xiu Zhai, Ian H Stevenson and Monty A Escabí

The NIH public access policy did not harm biomedical journals pp. 1-7

A Townsend Peterson, Paul E Johnson, Narayani Barve, Ada Emmett, Marc L Greenberg, Josh Bolick and Huijie Qiao

Song playbacks demonstrate slower evolution of song discrimination in birds from Amazonia than from temperate North America pp. 1-19

Jason T Weir and Trevor D Price

Volume 17, issue 8, 2019

Identification of traits and functional connectivity-based neurotraits of chronic pain pp. 1-24

Etienne Vachon-Presseau, Sara E Berger, Taha B Abdullah, James W Griffith, Thomas J Schnitzer and A Vania Apkarian

mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice pp. 1-25

Zi-Yang Zhang, Hu-Hu Bai, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Yong-Xing He and Xiao-Dong Hu

Coordinated circadian timing through the integration of local inputs in Arabidopsis thaliana pp. 1-31

Mark Greenwood, Mirela Domijan, Peter D Gould, Anthony J W Hall and James C W Locke

Strategic deployment of feature-based attentional gain in primate visual cortex pp. 1-28

Vladislav Kozyrev, Mohammad Reza Daliri, Philipp Schwedhelm and Stefan Treue

Volume 17, issue 7, 2019

Social intolerance is a consequence, not a cause, of dispersal in spiders pp. 1-27

Violette Chiara, Felipe Ramon Portugal and Raphael Jeanson

Spectral fingerprints or spectral tilt? Evidence for distinct oscillatory signatures of memory formation pp. 1-30

Marie-Christin Fellner, Stephanie Gollwitzer, Stefan Rampp, Gernot Kreiselmeyr, Daniel Bush, Beate Diehl, Nikolai Axmacher, Hajo Hamer and Simon Hanslmayr

Volume 17, issue 6, 2019

Evolution or revolution? Changing the way science is published and communicated pp. 1-5

Buzz Baum and Enrico Coen

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii pp. 1-24

Katharina B Böndel, Susanne A Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W Ness, Nick Colegrave and Peter D Keightley

Pleiotropy and synergistic cooperation pp. 1-3

David C Queller

Plan U: Universal access to scientific and medical research via funder preprint mandates pp. 1-4

Richard Sever, Michael Eisen and John Inglis

Improving big citizen science data: Moving beyond haphazard sampling pp. 1-11

Corey T Callaghan, Jodi J L Rowley, William K Cornwell, Alistair G B Poore and Richard E Major

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody pp. 1-29

Sunita Gulati, Frank J Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Nancy A Nowak, Ronald P Taylor, Marina Botto, Xianbao He, Robin R Ingalls, Trent M Woodruff, Wen-Chao Song, Janine Schuurman, Peter A Rice and Sanjay Ram

Volume 17, issue 5, 2019

Microstructural and functional gradients are increasingly dissociated in transmodal cortices pp. 1-28

Casey Paquola, Reinder Vos De Wael, Konrad Wagstyl, Richard A I Bethlehem, Seok-Jun Hong, Jakob Seidlitz, Edward T Bullmore, Alan C Evans, Bratislav Misic, Daniel S Margulies, Jonathan Smallwood and Boris C Bernhardt

Open science challenges, benefits and tips in early career and beyond pp. 1-14

Christopher Allen and David M A Mehler

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis pp. 1-23

Joshua L Payne, Fabrizio Menardo, Andrej Trauner, Sonia Borrell, Sebastian M Gygli, Chloe Loiseau, Sebastien Gagneux and Alex R Hall

Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis pp. 1-34

Gillian L Currie, Helena N Angel-Scott, Lesley Colvin, Fala Cramond, Kaitlyn Hair, Laila Khandoker, Jing Liao, Malcolm Macleod, Sarah K McCann, Rosie Morland, Nicki Sherratt, Robert Stewart, Ezgi Tanriver-Ayder, James Thomas, Qianying Wang, Rachel Wodarski, Ran Xiong, Andrew S C Rice and Emily S Sena

Volume 17, issue 4, 2019

Questioning the evidence for BCI-based communication in the complete locked-in state pp. 1-5

Martin Spüler

The amplitude in periodic neural state trajectories underlies the tempo of rhythmic tapping pp. 1-32

Jorge Gámez, Germán Mendoza, Luis Prado, Abraham Betancourt and Hugo Merchant

Thought-based interaction: Same data, same methods, different results? pp. 1-7

Reinhold Scherer

Exact replication: Foundation of science or game of chance? pp. 1-9

Sophie K Piper, Ulrike Grittner, Andre Rex, Nico Riedel, Felix Fischer, Robert Nadon, Bob Siegerink and Ulrich Dirnagl

Volume 17, issue 3, 2019

Biodiversity data integration—the significance of data resolution and domain pp. 1-16

Christian König, Patrick Weigelt, Julian Schrader, Amanda Taylor, Jens Kattge and Holger Kreft

PlotsOfData—A web app for visualizing data together with their summaries pp. 1-8

Marten Postma and Joachim Goedhart

Chronotopic maps in human supplementary motor area pp. 1-34

Foteini Protopapa, Masamichi J Hayashi, Shrikanth Kulashekhar, Wietske van der Zwaag, Giovanni Battistella, Micah M Murray, Ryota Kanai and Domenica Bueti

Volume 17, issue 2, 2019

A proposal for the future of scientific publishing in the life sciences pp. 1-10

Bodo M Stern and Erin K O’Shea

On the value of preprints: An early career researcher perspective pp. 1-12

Sarvenaz Sarabipour, Humberto J Debat, Edward Emmott, Steven J Burgess, Benjamin Schwessinger and Zach Hensel

Scrutinizing assortative mating in birds pp. 1-20

Daiping Wang, Wolfgang Forstmeier, Mihai Valcu, Niels J Dingemanse, Martin Bulla, Christiaan Both, Renée A Duckworth, Lynna Marie Kiere, Patrik Karell, Tomáš Albrecht and Bart Kempenaers

Fast near-whole–brain imaging in adult Drosophila during responses to stimuli and behavior pp. 1-31

Sophie Aimon, Takeo Katsuki, Tongqiu Jia, Logan Grosenick, Michael Broxton, Karl Deisseroth, Terrence J Sejnowski and Ralph J Greenspan

A census-based estimate of Earth's bacterial and archaeal diversity pp. 1-30

Stilianos Louca, Florent Mazel, Michael Doebeli and Laura Wegener Parfrey

Microglia exit the CNS in spinal root avulsion pp. 1-30

Lauren A Green, Julia C Nebiolo and Cody J Smith

A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions pp. 1-26

Maria E Yurgel, Priyanka Kakad, Meet Zandawala, Dick R Nässel, Tanja A Godenschwege and Alex C Keene

Attention promotes the neural encoding of prediction errors pp. 1-22

Cooper A Smout, Matthew F Tang, Marta I Garrido and Jason B Mattingley

A novel nonosteocytic regulatory mechanism of bone modeling pp. 1-22

Lior Ofer, Mason N Dean, Paul Zaslansky, Shiri Kult, Yulia Shwartz, Janna Zaretsky, Shelley Griess-Fishheimer, Efrat Monsonego-Ornan, Elazar Zelzer and Ron Shahar

Volume 17, issue 1, 2019

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport pp. 1-33

Ricardo Celestino, Morkos A Henen, José B Gama, Cátia Carvalho, Maxwell McCabe, Daniel J Barbosa, Alexandra Born, Parker J Nichols, Ana X Carvalho, Reto Gassmann and Beat Vögeli

Open notebook science can maximize impact for rare disease projects pp. 1-4

Rachel J Harding

Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis pp. 1-32

Abhijith Makki, Petr Rada, Vojtěch Žárský, Sami Kereïche, Lubomír Kováčik, Marian Novotný, Tobias Jores, Doron Rapaport and Jan Tachezy

Evidence that nonsignificant results are sometimes preferred: Reverse P-hacking or selective reporting? pp. 1-7

Pierre J C Chuard, Milan Vrtílek, Megan L Head and Michael D Jennions

Contest models highlight inherent inefficiencies of scientific funding competitions pp. 1-15

Kevin Gross and Carl T Bergstrom