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PLOS Biology

2003 - 2025

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Volume 18, issue 12, 2020

Ensuring the quality and specificity of preregistrations pp. 1-18 Downloads
Marjan Bakker, Coosje L S Veldkamp, Marcel A L M van Assen, Elise A V Crompvoets, How Hwee Ong, Brian A Nosek, Courtney K Soderberg, David Mellor and Jelte M Wicherts
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient pp. 1-35 Downloads
Jongbo Lee, Jumin Park, Ji-hyung Kim, Giwook Lee, Tae-Eun Park, Ki-Jun Yoon, Yoon Ki Kim and Chunghun Lim
Patterns of smallpox mortality in London, England, over three centuries pp. 1-27 Downloads
Olga Krylova and David J D Earn
The actions of others act as a pseudo-reward to drive imitation in the context of social reinforcement learning pp. 1-25 Downloads
Anis Najar, Emmanuelle Bonnet, Bahador Bahrami and Stefano Palminteri
Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism pp. 1-25 Downloads
Albert Zhang, Ziqiang Guan, Kyle Ockerman, Pengyuan Dong, Jiansheng Guo, Zhiping Wang and Dong Yan
Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx–dependent pyroptosis in intestinal epithelial cells pp. 1-31 Downloads
Qiyun Zhong, Theodoros I Roumeliotis, Zuza Kozik, Massiel Cepeda-Molero, Luis Ángel Fernández, Avinash R Shenoy, Chris Bakal, Gad Frankel and Jyoti S Choudhary
Generalizable brain network markers of major depressive disorder across multiple imaging sites pp. 1-26 Downloads
Ayumu Yamashita, Yuki Sakai, Takashi Yamada, Noriaki Yahata, Akira Kunimatsu, Naohiro Okada, Takashi Itahashi, Ryuichiro Hashimoto, Hiroto Mizuta, Naho Ichikawa, Masahiro Takamura, Go Okada, Hirotaka Yamagata, Kenichiro Harada, Koji Matsuo, Saori C Tanaka, Mitsuo Kawato, Kiyoto Kasai, Nobumasa Kato, Hidehiko Takahashi, Yasumasa Okamoto, Okito Yamashita and Hiroshi Imamizu

Volume 18, issue 11, 2020

We need to keep a reproducible trace of facts, predictions, and hypotheses from gene to function in the era of big data pp. 1-10 Downloads
Simon Kasif and Richard J Roberts
NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype pp. 1-25 Downloads
Mahmoud H Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M H Schiffers, Ger M Janssen, Pamela W M Kleikers, Anil Wipat, Jan Baumbach, Jo G R De Mey and Harald H H W Schmidt
EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis pp. 1-24 Downloads
Manon Gervais, Gwenaël Labouèbe, Alexandre Picard, Bernard Thorens and Sophie Croizier
Many, but not all, lineage-specific genes can be explained by homology detection failure pp. 1-24 Downloads
Caroline M Weisman, Andrew W Murray and Sean R Eddy
Rules warp feature encoding in decision-making circuits pp. 1-38 Downloads
R Becket Ebitz, Jiaxin Cindy Tu and Benjamin Y Hayden

Volume 18, issue 10, 2020

Optimising risk-based surveillance for early detection of invasive plant pathogens pp. 1-25 Downloads
Alexander J Mastin, Timothy R Gottwald, Frank van den Bosch, Nik J Cunniffe and Stephen Parnell
The COVID-19 response illustrates that traditional academic reward structures and metrics do not reflect crucial contributions to modern science pp. 1-3 Downloads
Adam J Kucharski, Sebastian Funk and Rosalind M Eggo
Updated science-wide author databases of standardized citation indicators pp. 1-3 Downloads
John P A Ioannidis, Kevin W Boyack and Jeroen Baas
Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia–thalamic communication pp. 1-38 Downloads
Bettina C Schwab, Daisuke Kase, Andrew Zimnik, Robert Rosenbaum, Marcello G Codianni, Jonathan E Rubin and Robert S Turner

Volume 18, issue 9, 2020

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies pp. 1-37 Downloads
Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T. Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan S Shaw, Eric K Moses, Dianna J Magliano and Peter J Meikle
Evolutionary dynamics in the Anthropocene: Life history and intensity of human contact shape antipredator responses pp. 1-17 Downloads
Benjamin Geffroy, Bastien Sadoul, Breanna J Putman, Oded Berger-Tal, László Zsolt Garamszegi, Anders Pape Møller and Daniel T Blumstein

Volume 18, issue 8, 2020

The right temporoparietal junction enables delay of gratification by allowing decision makers to focus on future events pp. 1-20 Downloads
Alexander Soutschek, Marius Moisa, Christian C Ruff and Philippe N Tobler
Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us pp. 1-6 Downloads
Carolyn Coyne, Jimmy D Ballard and Ira J Blader

Volume 18, issue 7, 2020

The Hong Kong Principles for assessing researchers: Fostering research integrity pp. 1-14 Downloads
David Moher, Lex Bouter, Sabine Kleinert, Paul Glasziou, Mai Har Sham, Virginia Barbour, Anne-Marie Coriat, Nicole Foeger and Ulrich Dirnagl
Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma pp. 1-17 Downloads
Shoya Iwanami, Kosaku Kitagawa, Hirofumi Ohashi, Yusuke Asai, Kaho Shionoya, Wakana Saso, Kazane Nishioka, Hisashi Inaba, Shinji Nakaoka, Takaji Wakita, Odo Diekmann, Shingo Iwami and Koichi Watashi
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research pp. 1-12 Downloads
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T Holgate, David W Howells, Natasha A Karp, Stanley E Lazic, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole H Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler and Hanno Würbel

Volume 18, issue 6, 2020

Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion pp. 1-31 Downloads
Salim T Islam, Israel Vergara Alvarez, Fares Saïdi, Annick Guiseppi, Evgeny Vinogradov, Gaurav Sharma, Leon Espinosa, Castrese Morrone, Gael Brasseur, Jean-François Guillemot, Anaïs Benarouche, Jean-Luc Bridot, Gokulakrishnan Ravicoularamin, Alain Cagna, Charles Gauthier, Mitchell Singer, Henri-Pierre Fierobe, Tâm Mignot and Emilia M F Mauriello

Volume 18, issue 5, 2020

Dynamical footprints enable detection of disease emergence pp. 1-20 Downloads
Tobias S Brett and Pejman Rohani
Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations pp. 1-20 Downloads
Elsa Hansen, Jason Karslake, Robert J Woods, Andrew F Read and Kevin B Wood

Volume 18, issue 3, 2020

Eco-evolutionary significance of “loners” pp. 1-27 Downloads
Fernando W Rossine, Ricardo Martinez-Garcia, Allyson E Sgro, Thomas Gregor and Corina E Tarnita
Interactive youth science workshops benefit student participants and graduate student mentors pp. 1-10 Downloads
Pallavi Kompella, Brant Gracia, Lucy LeBlanc, Shelly Engelman, Chinmayee Kulkarni, Niral Desai, Viviana June, Stephen March, Sarah Pattengale, Gabriel Rodriguez-Rivera, Seung Woo Ryu, Isabel Strohkendl, Pooja Mandke and Greg Clark
Context effects on probability estimation pp. 1-45 Downloads
Wei-Hsiang Lin, Justin L Gardner and Shih-Wei Wu
Bacterially produced metabolites protect C. elegans neurons from degeneration pp. 1-31 Downloads
Arles Urrutia, Víctor A García-Angulo, Andrés Fuentes, Mauricio Caneo, Marcela Legüe, Sebastián Urquiza, Scarlett E Delgado, Juan Ugalde, Paula Burdisso and Andrea Calixto

Volume 18, issue 2, 2020

Macroalgal germplasm banking for conservation, food security, and industry pp. 1-10 Downloads
Rachael Wade, Simona Augyte, Maddelyn Harden, Sergey Nuzhdin, Charles Yarish and Filipe Alberto

Volume 18, issue 1, 2020

PlotTwist: A web app for plotting and annotating continuous data pp. 1-10 Downloads
Joachim Goedhart
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity pp. 1-28 Downloads
Courtney A Lovejoy, Kaori Takai, Michael S Huh, David J Picketts and Titia de Lange

Volume 17, issue 12, 2019

High-order interactions distort the functional landscape of microbial consortia pp. 1-34 Downloads
Alicia Sanchez-Gorostiaga, Djordje Bajić, Melisa L Osborne, Juan F Poyatos and Alvaro Sanchez
Coinfections by noninteracting pathogens are not independent and require new tests of interaction pp. 1-25 Downloads
Frédéric M Hamelin, Linda J S Allen, Vrushali A Bokil, Louis J Gross, Frank M Hilker, Michael J Jeger, Carrie A Manore, Alison G Power, Megan A Rúa and Nik J Cunniffe

Volume 17, issue 11, 2019

All or nothing: No half-Merge and the evolution of syntax pp. 1-5 Downloads
Robert C Berwick and Noam Chomsky
Development, environmental degradation, and disease spread in the Brazilian Amazon pp. 1-8 Downloads
Marcia C Castro, Andres Baeza, Cláudia Torres Codeço, Zulma M Cucunubá, Ana Paula Dal’Asta, Giulio A De Leo, Andrew P Dobson, Gabriel Carrasco-Escobar, Raquel Martins Lana, Rachel Lowe, Antonio Miguel Vieira Monteiro, Mercedes Pascual and Mauricio Santos-Vega
Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias pp. 1-15 Downloads
Shir Mandelboum, Zohar Manber, Orna Elroy-Stein and Ran Elkon
Data-driven analyses of motor impairments in animal models of neurological disorders pp. 1-30 Downloads
Hardeep Ryait, Edgar Bermudez-Contreras, Matthew Harvey, Jamshid Faraji, Behroo Mirza Agha, Andrea Gomez-Palacio Schjetnan, Aaron Gruber, Jon Doan, Majid Mohajerani, Gerlinde A S Metz, Ian Q Whishaw and Artur Luczak
Neuroimaging-based prediction of mental traits: Road to utopia or Orwell? pp. 1-6 Downloads
Simon B Eickhoff and Robert Langner

Volume 17, issue 10, 2019

The NIH public access policy did not harm biomedical journals pp. 1-7 Downloads
A Townsend Peterson, Paul E Johnson, Narayani Barve, Ada Emmett, Marc L Greenberg, Josh Bolick and Huijie Qiao
Song playbacks demonstrate slower evolution of song discrimination in birds from Amazonia than from temperate North America pp. 1-19 Downloads
Jason T Weir and Trevor D Price
Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance pp. 1-34 Downloads
Jeff Maltas and Kevin B Wood
Refining animal research: The Animal Study Registry pp. 1-12 Downloads
Bettina Bert, Céline Heinl, Justyna Chmielewska, Franziska Schwarz, Barbara Grune, Andreas Hensel, Matthias Greiner and Gilbert Schönfelder
Predicting translational progress in biomedical research pp. 1-25 Downloads
B Ian Hutchins, Matthew T Davis, Rebecca A Meseroll and George M Santangelo
A neural ensemble correlation code for sound category identification pp. 1-41 Downloads
Mina Sadeghi, Xiu Zhai, Ian H Stevenson and Monty A Escabí

Volume 17, issue 8, 2019

Coordinated circadian timing through the integration of local inputs in Arabidopsis thaliana pp. 1-31 Downloads
Mark Greenwood, Mirela Domijan, Peter D Gould, Anthony J W Hall and James C W Locke
Strategic deployment of feature-based attentional gain in primate visual cortex pp. 1-28 Downloads
Vladislav Kozyrev, Mohammad Reza Daliri, Philipp Schwedhelm and Stefan Treue
mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice pp. 1-25 Downloads
Zi-Yang Zhang, Hu-Hu Bai, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Yong-Xing He and Xiao-Dong Hu
Identification of traits and functional connectivity-based neurotraits of chronic pain pp. 1-24 Downloads
Etienne Vachon-Presseau, Sara E Berger, Taha B Abdullah, James W Griffith, Thomas J Schnitzer and A Vania Apkarian

Volume 17, issue 7, 2019

Spectral fingerprints or spectral tilt? Evidence for distinct oscillatory signatures of memory formation pp. 1-30 Downloads
Marie-Christin Fellner, Stephanie Gollwitzer, Stefan Rampp, Gernot Kreiselmeyr, Daniel Bush, Beate Diehl, Nikolai Axmacher, Hajo Hamer and Simon Hanslmayr
Social intolerance is a consequence, not a cause, of dispersal in spiders pp. 1-27 Downloads
Violette Chiara, Felipe Ramon Portugal and Raphael Jeanson

Volume 17, issue 6, 2019

Plan U: Universal access to scientific and medical research via funder preprint mandates pp. 1-4 Downloads
Richard Sever, Michael Eisen and John Inglis
Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody pp. 1-29 Downloads
Sunita Gulati, Frank J Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Nancy A Nowak, Ronald P Taylor, Marina Botto, Xianbao He, Robin R Ingalls, Trent M Woodruff, Wen-Chao Song, Janine Schuurman, Peter A Rice and Sanjay Ram
Pleiotropy and synergistic cooperation pp. 1-3 Downloads
David C Queller
Evolution or revolution? Changing the way science is published and communicated pp. 1-5 Downloads
Buzz Baum and Enrico Coen
Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii pp. 1-24 Downloads
Katharina B Böndel, Susanne A Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W Ness, Nick Colegrave and Peter D Keightley
Improving big citizen science data: Moving beyond haphazard sampling pp. 1-11 Downloads
Corey T Callaghan, Jodi J L Rowley, William K Cornwell, Alistair G B Poore and Richard E Major

Volume 17, issue 5, 2019

Microstructural and functional gradients are increasingly dissociated in transmodal cortices pp. 1-28 Downloads
Casey Paquola, Reinder Vos De Wael, Konrad Wagstyl, Richard A I Bethlehem, Seok-Jun Hong, Jakob Seidlitz, Edward T Bullmore, Alan C Evans, Bratislav Misic, Daniel S Margulies, Jonathan Smallwood and Boris C Bernhardt
Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis pp. 1-23 Downloads
Joshua L Payne, Fabrizio Menardo, Andrej Trauner, Sonia Borrell, Sebastian M Gygli, Chloe Loiseau, Sebastien Gagneux and Alex R Hall
Open science challenges, benefits and tips in early career and beyond pp. 1-14 Downloads
Christopher Allen and David M A Mehler
Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis pp. 1-34 Downloads
Gillian L Currie, Helena N Angel-Scott, Lesley Colvin, Fala Cramond, Kaitlyn Hair, Laila Khandoker, Jing Liao, Malcolm Macleod, Sarah K McCann, Rosie Morland, Nicki Sherratt, Robert Stewart, Ezgi Tanriver-Ayder, James Thomas, Qianying Wang, Rachel Wodarski, Ran Xiong, Andrew S C Rice and Emily S Sena

Volume 17, issue 4, 2019

Exact replication: Foundation of science or game of chance? pp. 1-9 Downloads
Sophie K Piper, Ulrike Grittner, Andre Rex, Nico Riedel, Felix Fischer, Robert Nadon, Bob Siegerink and Ulrich Dirnagl
Thought-based interaction: Same data, same methods, different results? pp. 1-7 Downloads
Reinhold Scherer
The amplitude in periodic neural state trajectories underlies the tempo of rhythmic tapping pp. 1-32 Downloads
Jorge Gámez, Germán Mendoza, Luis Prado, Abraham Betancourt and Hugo Merchant
Questioning the evidence for BCI-based communication in the complete locked-in state pp. 1-5 Downloads
Martin Spüler

Volume 17, issue 3, 2019

Chronotopic maps in human supplementary motor area pp. 1-34 Downloads
Foteini Protopapa, Masamichi J Hayashi, Shrikanth Kulashekhar, Wietske van der Zwaag, Giovanni Battistella, Micah M Murray, Ryota Kanai and Domenica Bueti
Biodiversity data integration—the significance of data resolution and domain pp. 1-16 Downloads
Christian König, Patrick Weigelt, Julian Schrader, Amanda Taylor, Jens Kattge and Holger Kreft
PlotsOfData—A web app for visualizing data together with their summaries pp. 1-8 Downloads
Marten Postma and Joachim Goedhart

Volume 17, issue 2, 2019

A census-based estimate of Earth's bacterial and archaeal diversity pp. 1-30 Downloads
Stilianos Louca, Florent Mazel, Michael Doebeli and Laura Wegener Parfrey
Microglia exit the CNS in spinal root avulsion pp. 1-30 Downloads
Lauren A Green, Julia C Nebiolo and Cody J Smith
A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions pp. 1-26 Downloads
Maria E Yurgel, Priyanka Kakad, Meet Zandawala, Dick R Nässel, Tanja A Godenschwege and Alex C Keene
Fast near-whole–brain imaging in adult Drosophila during responses to stimuli and behavior pp. 1-31 Downloads
Sophie Aimon, Takeo Katsuki, Tongqiu Jia, Logan Grosenick, Michael Broxton, Karl Deisseroth, Terrence J Sejnowski and Ralph J Greenspan
On the value of preprints: An early career researcher perspective pp. 1-12 Downloads
Sarvenaz Sarabipour, Humberto J Debat, Edward Emmott, Steven J Burgess, Benjamin Schwessinger and Zach Hensel
A proposal for the future of scientific publishing in the life sciences pp. 1-10 Downloads
Bodo M Stern and Erin K O’Shea
Attention promotes the neural encoding of prediction errors pp. 1-22 Downloads
Cooper A Smout, Matthew F Tang, Marta I Garrido and Jason B Mattingley
A novel nonosteocytic regulatory mechanism of bone modeling pp. 1-22 Downloads
Lior Ofer, Mason N Dean, Paul Zaslansky, Shiri Kult, Yulia Shwartz, Janna Zaretsky, Shelley Griess-Fishheimer, Efrat Monsonego-Ornan, Elazar Zelzer and Ron Shahar
Scrutinizing assortative mating in birds pp. 1-20 Downloads
Daiping Wang, Wolfgang Forstmeier, Mihai Valcu, Niels J Dingemanse, Martin Bulla, Christiaan Both, Renée A Duckworth, Lynna Marie Kiere, Patrik Karell, Tomáš Albrecht and Bart Kempenaers

Volume 17, issue 1, 2019

Contest models highlight inherent inefficiencies of scientific funding competitions pp. 1-15 Downloads
Kevin Gross and Carl T Bergstrom
Open notebook science can maximize impact for rare disease projects pp. 1-4 Downloads
Rachel J Harding
A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport pp. 1-33 Downloads
Ricardo Celestino, Morkos A Henen, José B Gama, Cátia Carvalho, Maxwell McCabe, Daniel J Barbosa, Alexandra Born, Parker J Nichols, Ana X Carvalho, Reto Gassmann and Beat Vögeli
Evidence that nonsignificant results are sometimes preferred: Reverse P-hacking or selective reporting? pp. 1-7 Downloads
Pierre J C Chuard, Milan Vrtílek, Megan L Head and Michael D Jennions
Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis pp. 1-32 Downloads
Abhijith Makki, Petr Rada, Vojtěch Žárský, Sami Kereïche, Lubomír Kováčik, Marian Novotný, Tobias Jores, Doron Rapaport and Jan Tachezy
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