PLOS Medicine

2004 - 2025

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Volume 19, issue 12, 2022

Estimated economic burden of genital herpes and HIV attributable to herpes simplex virus type 2 infections in 90 low- and middle-income countries: A modeling study pp. 1-18

Sachin Silva, Houssein H Ayoub, Christine Johnston, Rifat Atun and Laith J Abu-Raddad

When less is more: The way forward for mental health interventions during the perinatal period pp. 1-3

Mark Tomlinson and Mary Jane Rotheram-Borus

Care cascades for hypertension and diabetes: Cross-sectional evaluation of rural districts in Tanzania pp. 1-17

Brianna Osetinsky, Grace Mhalu, Sally Mtenga and Fabrizio Tediosi

Addressing the diagnostic gap in hypertension through possible interventions and scale-up: A microsimulation study pp. 1-14

Lisa Koeppel, Sabine Dittrich, Sergio Brenner Miguel, Sergio Carmona, Stefano Ongarello, Beatrice Vetter, Jennifer Elizabeth Cohn, Till Baernighausen, Pascal Geldsetzer, Claudia M Denkinger and Consortium Hpacc

Volume 19, issue 11, 2022

Post-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany pp. 1-22

Martin Roessler, Falko Tesch, Manuel Batram, Josephine Jacob, Friedrich Loser, Oliver Weidinger, Danny Wende, Annika Vivirito, Nicole Toepfner, Franz Ehm, Martin Seifert, Oliver Nagel, Christina König, Roland Jucknewitz, Jakob Peter Armann, Reinhard Berner, Marina Treskova-Schwarzbach, Dagmar Hertle, Stefan Scholz, Stefan Stern, Pedro Ballesteros, Stefan Baßler, Barbara Bertele, Uwe Repschläger, Nico Richter, Cordula Riederer, Franziska Sobik, Anja Schramm, Claudia Schulte, Lothar Wieler, Jochen Walker, Christa Scheidt-Nave and Jochen Schmitt

Evaluation of physical activity calorie equivalent (PACE) labels’ impact on energy purchased in cafeterias: A stepped-wedge randomised controlled trial pp. 1-18

James P Reynolds, Minna Ventsel, Alice Hobson, Mark A Pilling, Rachel Pechey, Susan A Jebb, Gareth J Hollands and Theresa M Marteau

The association between multimorbidity and mobility disability-free life expectancy in adults aged 85 years and over: A modelling study in the Newcastle 85+ cohort pp. 1-17

Laurie E Davies, Stewart W Mercer, Katie Brittain, Carol Jagger, Louise Robinson and Andrew Kingston

Global SARS-CoV-2 seroprevalence from January 2020 to April 2022: A systematic review and meta-analysis of standardized population-based studies pp. 1-24

Isabel Bergeri, Mairead G Whelan, Harriet Ware, Lorenzo Subissi, Anthony Nardone, Hannah C Lewis, Zihan Li, Xiaomeng Ma, Marta Valenciano, Brianna Cheng, Lubna Al Ariqi, Arash Rashidian, Joseph Okeibunor, Tasnim Azim, Pushpa Wijesinghe, Linh-Vi Le, Aisling Vaughan, Richard Pebody, Andrea Vicari, Tingting Yan, Mercedes Yanes-Lane, Christian Cao, David A Clifton, Matthew P Cheng, Jesse Papenburg, David Buckeridge, Niklas Bobrovitz, Rahul K Arora, Maria D Van Kerkhove and Unity Studies Collaborator Group

Volume 19, issue 10, 2022

Association of birthweight centiles and early childhood development of singleton infants born from 37 weeks of gestation in Scotland: A population-based cohort study pp. 1-21

Abiodun Adanikin, Deborah A Lawlor, Jill P Pell, Scott M Nelson, Gordon C S Smith and Stamatina Iliodromiti

Medicare eligibility and healthcare access, affordability, and financial strain for low- and higher-income adults in the United States: A regression discontinuity analysis pp. 1-19

Rahul Aggarwal, Robert W Yeh, Issa J Dahabreh, Sarah E Robertson and Rishi K Wadhera

Effectiveness of integrated care for older adults with depression and hypertension in rural China: A cluster randomized controlled trial pp. 1-18

Shulin Chen, Yeates Conwell, Jiang Xue, Lydia Li, Tingjie Zhao, Wan Tang, Hillary Bogner and Hengjin Dong

Volume 19, issue 9, 2022

Association of injury after prescription opioid initiation with risk for opioid-related adverse events among older Medicare beneficiaries in the United States: A nested case-control study pp. 1-16

Yu-Jung Jenny Wei, Cheng Chen, Ting-Yuan David Cheng, Siegfried O Schmidt, Roger B Fillingim and Almut G Winterstein

The global prevalence of female genital mutilation/cutting: A systematic review and meta-analysis of national, regional, facility, and school-based studies pp. 1-34

Leen Farouki, Zeinab El-Dirani, Sawsan Abdulrahim, Christelle Akl, Chaza Akik and Stephen J McCall

Volume 19, issue 8, 2022

Universal healthcare coverage and health service delivery before and during the COVID-19 pandemic: A difference-in-difference study of childhood immunization coverage from 195 countries pp. 1-18

Sooyoung Kim, Tyler Y Headley and Yesim Tozan

Income differences in COVID-19 incidence and severity in Finland among people with foreign and native background: A population-based cohort study of individuals nested within households pp. 1-22

Sanni Saarinen, Heta Moustgaard, Hanna Remes, Riikka Sallinen and Pekka Martikainen

Urban-rural differences in hypertension prevalence in low-income and middle-income countries, 1990–2020: A systematic review and meta-analysis pp. 1-19

Otavio T Ranzani, Anjani Kalra, Chiara Di Girolamo, Ariadna Curto, Fernanda Valerio, Jaana I Halonen, Xavier Basagaña and Cathryn Tonne

Effectiveness of a brief group behavioural intervention on psychological distress in young adolescent Syrian refugees: A randomised controlled trial pp. 1-21

Richard A Bryant, Aiysha Malik, Ibrahim Said Aqel, Maha Ghatasheh, Rand Habashneh, Katie S Dawson, Sarah Watts, Mark J D Jordans, Felicity L Brown, Mark van Ommeren and Aemal Akhtar

The performance of using dried blood spot specimens for HIV-1 viral load testing: A systematic review and meta-analysis pp. 1-34

Lara Vojnov, Sergio Carmona, Clement Zeh, Jessica Markby, Debrah Boeras, Marta R Prescott, Anthony L H Mayne, Souleymane Sawadogo, Christiane Adje-Toure, Guoqing Zhang, Mercedes Perez Gonzalez, Wendy S Stevens, Meg Doherty, Chunfu Yang, Heather Alexander, Trevor F Peter, John Nkengasong and the DBS for VL Diagnostics Investigation Consortium

Volume 19, issue 7, 2022

Implementation research on noncommunicable disease prevention and control interventions in low- and middle-income countries: A systematic review pp. 1-34

Celestin Hategeka, Prince Adu, Allissa Desloge, Robert Marten, Ruitai Shao, Maoyi Tian, Ting Wei and Margaret E Kruk

Global influenza surveillance systems to detect the spread of influenza-negative influenza-like illness during the COVID-19 pandemic: Time series outlier analyses from 2015–2020 pp. 1-18

Natalie L Cobb, Sigrid Collier, Engi F Attia, Orvalho Augusto, T Eoin West and Bradley H Wagenaar

Prevention of venous thromboembolic events in patients with lower leg immobilization after trauma: Systematic review and network meta-analysis with meta-epsidemiological approach pp. 1-18

D Douillet, C Chapelle, E Ollier, P Mismetti, Roy P-M and S Laporte

Performance bonuses and the quality of primary health care delivered by family health teams in Brazil: A difference-in-differences analysis pp. 1-19

Nasser Fardousi, Everton Nunes da Silva, Roxanne Kovacs, Josephine Borghi, Jorge O M Barreto, Søren Rud Kristensen, Juliana Sampaio, Helena Eri Shimizu, Luciano B Gomes, Letícia Xander Russo, Garibaldi D Gurgel and Timothy Powell-Jackson

Volume 19, issue 6, 2022

School racial segregation and long-term cardiovascular health among Black adults in the US: A quasi-experimental study pp. 1-19

Min Hee Kim, Gabriel L Schwartz, Justin S White, M Maria Glymour, Sean F Reardon, Kiarri N Kershaw, Scarlett Lin Gomez, Daniel F Collin, Pushkar P Inamdar, Guangyi Wang and Rita Hamad

Scaling up target regimens for tuberculosis preventive treatment in Brazil and South Africa: An analysis of costs and cost-effectiveness pp. 1-17

Ntwali Placide Nsengiyumva, Jonathon R Campbell, Olivia Oxlade, Juan F Vesga, Christian Lienhardt, Anete Trajman, Dennis Falzon, Saskia Den Boon, Nimalan Arinaminpathy and Kevin Schwartzman

Addressing the impacts of COVID-19 on refugee health pp. 1-2

Rebecca F Grais and Emmanuel Baron

Association of environmental and socioeconomic indicators with serious mental illness diagnoses identified from general practitioner practice data in England: A spatial Bayesian modelling study pp. 1-27

Joana Cruz, Guangquan Li, Maria Jose Aragon, Peter A Coventry, Rowena Jacobs, Stephanie L Prady and Piran C L White

Volume 19, issue 5, 2022

Call for Papers: PLOS Medicine Special Issue on the COVID-19 Pandemic and Global Mental Health pp. 1-1

The PLOS Medicine Editors

Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: An updated systematic review and meta-analysis with meta-regression analyzing influencing factors pp. 1-34

Lukas E Brümmer, Stephan Katzenschlager, Sean McGrath, Stephani Schmitz, Mary Gaeddert, Christian Erdmann, Marc Bota, Maurizio Grilli, Jan Larmann, Markus A Weigand, Nira R Pollock, Aurélien Macé, Berra Erkosar, Sergio Carmona, Jilian A Sacks, Stefano Ongarello and Claudia M Denkinger

Call for Papers: PLOS Medicine Special Issue on Bacterial Antimicrobial Resistance—Surveillance and Prevention pp. 1-2

The PLOS Medicine Editors

Relationship between the Bolsa Família national cash transfer programme and suicide incidence in Brazil: A quasi-experimental study pp. 1-17

Daiane Borges Machado, Elizabeth Williamson, Julia M Pescarini, Flavia J O Alves, Luís F S Castro- de-Araujo, Maria Yury Ichihara, Laura C Rodrigues, Ricardo Araya, Vikram Patel and Maurício L Barreto

Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis pp. 1-30

Diana Buitrago-Garcia, Aziz Mert Ipekci, Leonie Heron, Hira Imeri, Lucia Araujo-Chaveron, Ingrid Arevalo-Rodriguez, Agustín Ciapponi, Muge Cevik, Anthony Hauser, Muhammad Irfanul Alam, Kaspar Meili, Eric A Meyerowitz, Nirmala Prajapati, Xueting Qiu, Aaron Richterman, William Gildardo Robles-Rodriguez, Shabnam Thapa, Ivan Zhelyazkov, Georgia Salanti and Nicola Low

Volume 19, issue 4, 2022

Food environment and diabetes mellitus in South Asia: A geospatial analysis of health outcome data pp. 1-20

Dian Kusuma, Petya Atanasova, Elisa Pineda, Ranjit Mohan Anjana, Laksara De Silva, Abu AM Hanif, Mehedi Hasan, Md Mokbul Hossain, Susantha Indrawansa, Deepal Jayamanne, Sujeet Jha, Anuradhani Kasturiratne, Prasad Katulanda, Khadija I Khawaja, Balachandran Kumarendran, Malay K Mridha, Vindya Rajakaruna, John C Chambers, Gary Frost, Franco Sassi and Marisa Miraldo

Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis pp. 1-25

Benjamin R Fletcher, Sarah Damery, Olalekan Lee Aiyegbusi, Nicola Anderson, Melanie Calvert, Paul Cockwell, James Ferguson, Mike Horton, Muirne C S Paap, Chris Sidey-Gibbons, Anita Slade, Neil Turner and Derek Kyte

Social justice now for an equitable tomorrow: Reflections from the Consortium of Universities for Global Health Conference 2022 pp. 1-4

Beryne Odeny and Callam Davidson

Patient-level interventions to reduce alcohol-related harms in low- and middle-income countries: A systematic review and meta-summary pp. 1-27

Catherine A Staton, João Ricardo Nickenig Vissoci, Deena El-Gabri, Konyinsope Adewumi, Tessa Concepcion, Shannon A Elliott, Daniel R Evans, Sophie W Galson, Charles T Pate, Lindy M Reynolds, Nadine A Sanchez, Alexandra E Sutton, Charlotte Yuan, Alena Pauley, Luciano Andrade, Megan Von Isenberg, Jinny J Ye and Charles J Gerardo

Temporal trends in associations between severe mental illness and risk of cardiovascular disease: A systematic review and meta-analysis pp. 1-32

Amanda M Lambert, Helen M Parretti, Emma Pearce, Malcolm J Price, Mark Riley, Ronan Ryan, Natalie Tyldesley-Marshall, Tuba Saygın Avşar, Gemma Matthewman, Alexandra Lee, Khaled Ahmed, Maria Lisa Odland, Christoph U Correll, Marco Solmi and Tom Marshall

Evaluation of an adapted version of the Diabetes Prevention Program for low- and middle-income countries: A cluster randomized trial to evaluate “Lifestyle Africa” in South Africa pp. 1-19

Delwyn Catley, Thandi Puoane, Lungiswa Tsolekile, Ken Resnicow, Kandace K Fleming, Emily A Hurley, Joshua M Smyth, Frank T Materia, Estelle V Lambert, Mara Z Vitolins, Naomi S Levitt and Kathy Goggin

Volume 19, issue 3, 2022

Interventions to reengage people living with HIV who are lost to follow-up from HIV treatment programs: A systematic review and meta-analysis pp. 1-26

Ali Mirzazadeh, Ingrid Eshun-Wilson, Ryan R Thompson, Atousa Bonyani, James G Kahn, Stefan D Baral, Sheree Schwartz, George Rutherford and Elvin H Geng

Visualising health risks with medical imaging for changing recipients’ health behaviours and risk factors: Systematic review with meta-analysis pp. 1-28

Gareth J Hollands, Juliet A Usher-Smith, Rana Hasan, Florence Alexander, Natasha Clarke and Simon J Griffin

Social determinants of the changing tuberculosis prevalence in Việt Nam: Analysis of population-level cross-sectional studies pp. 1-17

Nicola Foster, Hai V Nguyen, Nhung V Nguyen, Hoa B Nguyen, Edine W Tiemersma, Frank G J Cobelens, Matthew Quaife and Rein M G J Houben

Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: A comparison of longitudinal cohort studies pp. 1-25

Peter Hanlon, Bhautesh D Jani, Barbara Nicholl, Jim Lewsey, David A McAllister and Frances S Mair

Prevention of violence against women and girls: A cost-effectiveness study across 6 low- and middle-income countries pp. 1-31

Giulia Ferrari, Sergio Torres-Rueda, Esnat Chirwa, Andrew Gibbs, Stacey Orangi, Edwine Barasa, Theresa Tawiah, Rebecca Kyerewaa Dwommoh Prah, Regis Hitimana, Emmanuelle Daviaud, Eleonah Kapapa, Kristin Dunkle, Lori Heise, Erin Stern, Sangeeta Chatterji, Benjamin Omondi, Deda Ogum Alangea, Rozina Karmaliani, Hussain Maqbool Ahmed Khuwaja, Rachel Jewkes, Charlotte Watts and Anna Vassall

Concurrent use of prescription gabapentinoids with opioids and risk for fall-related injury among older US Medicare beneficiaries with chronic noncancer pain: A population-based cohort study pp. 1-18

Cheng Chen, Almut G Winterstein, Wei-Hsuan Lo-Ciganic, Patrick J Tighe and Yu-Jung Jenny Wei

Childhood factors associated with suicidal ideation among South African youth: A 28-year longitudinal study of the Birth to Twenty Plus cohort pp. 1-18

Massimiliano Orri, Marilyn N Ahun, Sara Naicker, Sahba Besharati and Linda M Richter

Trajectories of prescription opioid dose and risk of opioid-related adverse events among older Medicare beneficiaries in the United States: A nested case–control study pp. 1-18

Yu-Jung Jenny Wei, Cheng Chen, Motomori O Lewis, Siegfried O Schmidt and Almut G Winterstein

National adaptation and implementation of WHO Model List of Essential Medicines: A qualitative evidence synthesis pp. 1-23

Elizabeth F Peacocke, Sonja L Myhre, Hakan Safaralilo Foss and Unni Gopinathan

Volume 19, issue 2, 2022

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study pp. 1-20

Evangelos Kontopantelis, Mamas A Mamas, Roger T Webb, Ana Castro, Martin K Rutter, Chris P Gale, Darren M Ashcroft, Matthias Pierce, Kathryn M Abel, Gareth Price, Corinne Faivre-Finn, Harriette G C Van Spall, Michelle M Graham, Marcello Morciano, Glen P Martin, Matt Sutton and Tim Doran

Risks of specific congenital anomalies in offspring of women with diabetes: A systematic review and meta-analysis of population-based studies including over 80 million births pp. 1-25

Tie-Ning Zhang, Xin-Mei Huang, Xin-Yi Zhao, Wei Wang, Ri Wen and Shan-Yan Gao

Estimating impact of food choices on life expectancy: A modeling study pp. 1-17

Lars T Fadnes, Jan-Magnus Økland, Øystein A Haaland and Kjell Arne Johansson

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study pp. 1-17

Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S V Shah, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D Shah, Mark R Thursz, Paul Elliott, Harry Hemmingway, Bryan Williams, Folkert W Asselbergs, Michael O’Sullivan, Graham M Lord, Adam Trickey, Jonathan AC Sterne, Dorian O Haskard, Narbeh Melikian, Darrel P Francis, Wolfgang Koenig, Ajay M Shah, Rajesh Kharbanda, Divaka Perera, Riyaz S Patel, Keith M Channon, Jamil Mayet and Ramzi Khamis

Cost-effectiveness of antenatal multiple micronutrients and balanced energy protein supplementation compared to iron and folic acid supplementation in India, Pakistan, Mali, and Tanzania: A dynamic microsimulation study pp. 1-22

Nicole Young, Alison Bowman, Kjell Swedin, James Collins, Nathaniel D Blair-Stahn, Paulina A Lindstedt, Christopher Troeger and Abraham D Flaxman

Vaccine equity: A fundamental imperative in the fight against COVID-19 pp. 1-4

The PLOS Medicine Editors

Volume 19, issue 1, 2022

The impact of removing financial incentives and/or audit and feedback on chlamydia testing in general practice: A cluster randomised controlled trial (ACCEPt-able) pp. 1-18

Jane S Hocking, Anna Wood, Meredith Temple-Smith, Sabine Braat, Matthew Law, Liliana Bulfone, Callum Jones, Mieke van Driel, Christopher K Fairley, Basil Donovan, Rebecca Guy, Nicola Low, John Kaldor and Jane Gunn

Population sizes, HIV prevalence, and HIV prevention among men who paid for sex in sub-Saharan Africa (2000–2020): A meta-analysis of 87 population-based surveys pp. 1-18

Caroline Hodgins, James Stannah, Salome Kuchukhidze, Lycias Zembe, Jeffrey W Eaton, Marie-Claude Boily and Mathieu Maheu-Giroux

Political rationale, aims, and outcomes of health-related high-level meetings and special sessions at the UN General Assembly: A policy research observational study pp. 1-18

Paolo Rodi, Werner Obermeyer, Ariel Pablos-Mendez, Andrea Gori and Mario C Raviglione

Hypertension awareness, treatment, and control and their association with healthcare access in the middle-aged and older Indian population: A nationwide cohort study pp. 1-20

Jinkook Lee, Jenny Wilkens, Erik Meijer, T V Sekher, David E Bloom and Peifeng Hu

Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials pp. 1-21

Erick H Turner, Andrea Cipriani, Toshi A Furukawa, Georgia Salanti and Ymkje Anna de Vries

Clinical impact of vivax malaria: A collection review pp. 1-23

Aung Pyae Phyo, Prabin Dahal, Mayfong Mayxay and Elizabeth A Ashley

Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis pp. 1-17

Geert-Jan Geersing, Toshihiko Takada, Frederikus A Klok, Harry R Büller, D Mark Courtney, Yonathan Freund, Javier Galipienzo, Gregoire Le Gal, Waleed Ghanima, Jeffrey A Kline, Menno V Huisman, Karel G M Moons, Arnaud Perrier, Sameer Parpia, Helia Robert-Ebadi, Marc Righini, Pierre-Marie Roy, Maarten van Smeden, Milou A M Stals, Philip S Wells, Kerstin de Wit, Noémie Kraaijpoel and Nick van Es