PLOS Genetics

2005 - 2022

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Volume 4, issue 12, 2008

The Population Genetics of dN/dS pp. 1-10

Sergey Kryazhimskiy and Joshua B Plotkin

Practical Issues in Imputation-Based Association Mapping pp. 1-11

Yongtao Guan and Matthew Stephens

Volume 4, issue 11, 2008

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines pp. 1-16

Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M Plenge, Richa Saxena, Philip L De Jager, Stanley Y Shaw, Cara S Wolfish, Jacqueline M Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J Daly and David Altshuler

Volume 4, issue 10, 2008

Efficient and Accurate Construction of Genetic Linkage Maps from the Minimum Spanning Tree of a Graph pp. 1-11

Yonghui Wu, Prasanna R Bhat, Timothy J Close and Stefano Lonardi

Volume 4, issue 9, 2008

An Approximate Bayesian Estimator Suggests Strong, Recurrent Selective Sweeps in Drosophila pp. 1-11

Jeffrey D Jensen, Kevin R Thornton and Peter Andolfatto

A Review of Family-Based Tests for Linkage Disequilibrium between a Quantitative Trait and a Genetic Marker pp. 1-6

Warren J Ewens, Mingyao Li and Richard S Spielman

Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected pp. 1-10

Amy Murphy, Scott T Weiss and Christoph Lange

Volume 4, issue 8, 2008

Linkage Disequilibrium-Based Quality Control for Large-Scale Genetic Studies pp. 1-9

Paul Scheet and Matthew Stephens

Identification and Functional Analysis of Light-Responsive Unique Genes and Gene Family Members in Rice pp. 1-19

Ki-Hong Jung, Jinwon Lee, Chris Dardick, Young-Su Seo, Peijian Cao, Patrick Canlas, Jirapa Phetsom, Xia Xu, Shu Ouyang, Kyungsook An, Yun-Ja Cho, Geun-Cheol Lee, Yoosook Lee, Gynheung An and Pamela C Ronald

A Tribute to Evgenii V. Ananiev, 1947–2008 pp. 1-3

Sergei M Mirkin

Volume 4, issue 7, 2008

Tracing Sub-Structure in the European American Population with PCA-Informative Markers pp. 1-13

Peristera Paschou, Petros Drineas, Jamey Lewis, Caroline M Nievergelt, Deborah A Nickerson, Joshua D Smith, Paul M Ridker, Daniel I Chasman, Ronald M Krauss and Elad Ziv

Zebrafish Whole-Adult-Organism Chemogenomics for Large-Scale Predictive and Discovery Chemical Biology pp. 1-14

Siew Hong Lam, Sinnakarupan Mathavan, Yan Tong, Haixia Li, R Krishna Murthy Karuturi, Yilian Wu, Vinsensius B Vega, Edison T Liu and Zhiyuan Gong

An Integrated Approach for the Analysis of Biological Pathways using Mixed Models pp. 1-9

Lily Wang, Bing Zhang, Russell D Wolfinger and Xi Chen

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction pp. 1-11

Robert B Weiss, Timothy B Baker, Dale S Cannon, Andrew von Niederhausern, Diane M Dunn, Nori Matsunami, Nanda A Singh, Lisa Baird, Hilary Coon, William M McMahon, Megan E Piper, Michael C Fiore, Mary Beth Scholand, John E Connett, Richard E Kanner, Lorise C Gahring, Scott W Rogers, John R Hoidal and Mark F Leppert

PLoS Genetics Turns Three: Looking Back, Looking Ahead pp. 1-2

Wayne N Frankel and Gregory S Barsh

Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies pp. 1-8

Clive J Hoggart, John C Whittaker, Maria De Iorio and David J Balding

Volume 4, issue 6, 2008

A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2 pp. 1-17

Monica Chang, Charles M Rowland, Veronica E Garcia, Steven J Schrodi, Joseph J Catanese, Annette H M van der Helm-van Mil, Kristin G Ardlie, Christopher I Amos, Lindsey A Criswell, Daniel L Kastner, Peter K Gregersen, Fina A S Kurreeman, Rene E M Toes, Tom W J Huizinga, Michael F Seldin and Ann B Begovich

Evaluating Statistical Methods Using Plasmode Data Sets in the Age of Massive Public Databases: An Illustration Using False Discovery Rates pp. 1-8

Gary L Gadbury, Qinfang Xiang, Lin Yang, Stephen Barnes, Grier P Page and David B Allison

Volume 4, issue 5, 2008

Inferring Human Colonization History Using a Copying Model pp. 1-11

Garrett Hellenthal, Adam Auton and Daniel Falush

Demographic History of European Populations of Arabidopsis thaliana pp. 1-15

Olivier François, Michael G B Blum, Mattias Jakobsson and Noah A Rosenberg

Volume 4, issue 2, 2008

Ready for Her Close-Up: An Interview with Elaine Strass pp. 1-4

Jane Gitschier

What Can Genome-Wide Association Studies Tell Us about the Genetics of Common Disease? pp. 1-8

Mark M Iles

Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries pp. 1-11

Ertuğrul M Özbudak and Julian Lewis

Volume 4, issue 1, 2008

Analysis and Application of European Genetic Substructure Using 300 K SNP Information pp. 1-11

Chao Tian, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Selmi, Lars Klareskog, Ann E Pulver, Lihong Qi, Peter K Gregersen and Michael F Seldin

Application of Ancestry Informative Markers to Association Studies in European Americans pp. 1-2

Michael F Seldin and Alkes L Price

Volume 3, issue 12, 2007

Entropy Explains Aging, Genetic Determinism Explains Longevity, and Undefined Terminology Explains Misunderstanding Both pp. 1-1

Leonard Hayflick

Volume 3, issue 11, 2007

AGEMAP: A Gene Expression Database for Aging in Mice pp. 1-12

Jacob M Zahn, Suresh Poosala, Art B Owen, Donald K Ingram, Ana Lustig, Arnell Carter, Ashani T Weeraratna, Dennis D Taub, Myriam Gorospe, Krystyna Mazan-Mamczarz, Edward G Lakatta, Kenneth R Boheler, Xiangru Xu, Mark P Mattson, Geppino Falco, Minoru S H Ko, David Schlessinger, Jeffrey Firman, Sarah K Kummerfeld, William H Wood, Alan B Zonderman, Stuart K Kim and Kevin G Becker

Volume 3, issue 10, 2007

Regulatory Pathway Analysis by High-Throughput In Situ Hybridization pp. 1-17

Axel Visel, James Carson, Judit Oldekamp, Marei Warnecke, Vladimira Jakubcakova, Xunlei Zhou, Chad A Shaw, Gonzalo Alvarez-Bolado and Gregor Eichele

Volume 3, issue 9, 2007

Linkage Analysis of a Model Quantitative Trait in Humans: Finger Ridge Count Shows Significant Multivariate Linkage to 5q14.1 pp. 1-9

Sarah E Medland, Danuta Z Loesch, Bogdan Mdzewski, Gu Zhu, Grant W Montgomery and Nicholas G Martin

Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis pp. 1-12

Jeffrey T Leek and John D Storey

Adaptive Evolution of Conserved Noncoding Elements in Mammals pp. 1-15

Su Yeon Kim and Jonathan K Pritchard

PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations pp. 1-15

Peristera Paschou, Elad Ziv, Esteban G Burchard, Shweta Choudhry, William Rodriguez-Cintron, Michael W Mahoney and Petros Drineas

Gene Expression Programs of Human Smooth Muscle Cells: Tissue-Specific Differentiation and Prognostic Significance in Breast Cancers pp. 1-15

Jen-Tsan Chi, Edwin H Rodriguez, Zhen Wang, Dimitry S A Nuyten, Sayan Mukherjee, Matt van de Rijn, Marc J van de Vijver, Trevor Hastie and Patrick O Brown

Volume 3, issue 8, 2007

Assessing the Significance of Conserved Genomic Aberrations Using High Resolution Genomic Microarrays pp. 1-23

Mitchell Guttman, Carolyn Mies, Katarzyna Dudycz-Sulicz, Sharon J Diskin, Don A Baldwin, Christian J Stoeckert and Gregory R Grant

Volume 3, issue 7, 2007

Genetic Association Mapping via Evolution-Based Clustering of Haplotypes pp. 1-15

Ioanna Tachmazidou, Claudio J Verzilli and Maria De Iorio

Volume 3, issue 6, 2007

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease pp. 1-12

Timothy G Lesnick, Spiridon Papapetropoulos, Deborah C Mash, Jarlath Ffrench-Mullen, Lina Shehadeh, Mariza de Andrade, John R Henley, Walter A Rocca, J Eric Ahlskog and Demetrius M Maraganore

Volume 3, issue 5, 2007

Allele-Specific Chromatin Immunoprecipitation Studies Show Genetic Influence on Chromatin State in Human Genome pp. 1-11

Mitsutaka Kadota, Howard H Yang, Nan Hu, Chaoyu Wang, Ying Hu, Philip R Taylor, Kenneth H Buetow and Maxwell P Lee

A Method to Address Differential Bias in Genotyping in Large-Scale Association Studies pp. 1-9

Vincent Plagnol, Jason D Cooper, John A Todd and David G Clayton

Volume 3, issue 4, 2007

Generalized Analysis of Molecular Variance pp. 1-12

Caroline M Nievergelt, Ondrej Libiger and Nicholas J Schork

Genetic Structure of Chimpanzee Populations pp. 1-10

Celine Becquet, Nick Patterson, Anne C Stone, Molly Przeworski and David Reich

Volume 3, issue 3, 2007

Incorporating Single-Locus Tests into Haplotype Cladistic Analysis in Case-Control Studies pp. 1-10

Jianfeng Liu, Chris Papasian and Hong-Wen Deng

Forward-Time Simulations of Human Populations with Complex Diseases pp. 1-14

Bo Peng, Christopher I Amos and Marek Kimmel

Off the Beaten Path: An Interview with Spencer Wells pp. 1-5

Jane Gitschier

Volume 2, issue 12, 2006

Soft Sweeps III: The Signature of Positive Selection from Recurrent Mutation pp. 1-15

Pleuni S Pennings and Joachim Hermisson

Population Structure and Eigenanalysis pp. 1-20

Nick Patterson, Alkes L Price and David Reich

Volume 2, issue 11, 2006

Authors' Reply pp. 1-2

Erik van Nimwegen and Mihaela Zavolan

Volume 2, issue 9, 2006

Twenty Paces from History: An Interview with Soraya de Chadarevian pp. 1-4

Jane Gitschier

Volume 2, issue 8, 2006

Are Molecular Haplotypes Worth the Time and Expense? A Cost-Effective Method for Applying Molecular Haplotypes pp. 1-11

Mark A Levenstien, Jürg Ott and Derek Gordon

Identification of Mitochondrial DNA Polymorphisms That Alter Mitochondrial Matrix pH and Intracellular Calcium Dynamics pp. 1-11

An-a Kazuno, Kae Munakata, Takeharu Nagai, Satoshi Shimozono, Masashi Tanaka, Makoto Yoneda, Nobumasa Kato, Atsushi Miyawaki and Tadafumi Kato

Regional Admixture Mapping and Structured Association Testing: Conceptual Unification and an Extensible General Linear Model pp. 1-11

David T Redden, Jasmin Divers, Laura Kelly Vaughan, Hemant K Tiwari, T Mark Beasley, José R Fernández, Robert P Kimberly, Rui Feng, Miguel A Padilla, Nianjun Liu, Michael B Miller and David B Allison

Family-Based versus Unrelated Case-Control Designs for Genetic Associations pp. 1-9

Evangelos Evangelou, Thomas A Trikalinos, Georgia Salanti and John P A Ioannidis

Volume 2, issue 7, 2006

Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs pp. 1-13

John L Rinn, Chanda Bondre, Hayes B Gladstone, Patrick O Brown and Howard Y Chang

Possible Ancestral Structure in Human Populations pp. 1-8

Vincent Plagnol and Jeffrey D Wall

Lymphotoxin-α Gene and Risk of Myocardial Infarction in 6,928 Cases and 2,712 Controls in the ISIS Case-Control Study pp. 1-7

Robert Clarke, Peng Xu, Derrick Bennett, Sarah Lewington, Krina Zondervan, Sarah Parish, Alison Palmer, Sarah Clark, Lon Cardon, Richard Peto, Mark Lathrop and Rory Collins

Structural Model Analysis of Multiple Quantitative Traits pp. 1-12

Renhua Li, Shirng-Wern Tsaih, Keith Shockley, Ioannis M Stylianou, Jon Wergedal, Beverly Paigen and Gary A Churchill

Volume 2, issue 6, 2006

Why Do Hubs Tend to Be Essential in Protein Networks? pp. 1-9

Xionglei He and Jianzhi Zhang

The Making of a President: An Interview with Shirley Tilghman pp. 1-4

Jane Gitschier

Volume 2, issue 5, 2006

High-Resolution Recombination Patterns in a Region of Human Chromosome 21 Measured by Sperm Typing pp. 1-11

Irene Tiemann-Boege, Peter Calabrese, David M Cochran, Rebecca Sokol and Norman Arnheim

Volume 2, issue 4, 2006

SPA: A Probabilistic Algorithm for Spliced Alignment pp. 1-19

Erik van Nimwegen, Nicodeme Paul, Robert Sheridan and Mihaela Zavolan

Mice and Men: Their Promoter Properties pp. 1-13

Vladimir B Bajic, Sin Lam Tan, Alan Christoffels, Christian Schönbach, Leonard Lipovich, Liang Yang, Oliver Hofmann, Adele Kruger, Winston Hide, Chikatoshi Kai, Jun Kawai, David A Hume, Piero Carninci and Yoshihide Hayashizaki

Volume 2, issue 3, 2006

The Dictyostelium Kinome—Analysis of the Protein Kinases from a Simple Model Organism pp. 1-13

Jonathan M Goldberg, Gerard Manning, Allen Liu, Petra Fey, Karen E Pilcher, Yanji Xu and Janet L Smith

An Evaluation of the Performance of Tag SNPs Derived from HapMap in a Caucasian Population pp. 1-9

Alexandre Montpetit, Mari Nelis, Philippe Laflamme, Reedik Magi, Xiayi Ke, Maido Remm, Lon Cardon, Thomas J Hudson and Andres Metspalu

CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure pp. 1-10

Christoph Bock, Martina Paulsen, Sascha Tierling, Thomas Mikeska, Thomas Lengauer and Jörn Walter

Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings pp. 1-10

Peter M Visscher, Sarah E Medland, Manuel A R Ferreira, Katherine I Morley, Gu Zhu, Belinda K Cornes, Grant W Montgomery and Nicholas G Martin

Volume 2, issue 2, 2006

DNA Sequences Shaped by Selection for Stability pp. 1-7

Martin Ackermann and Lin Chao

An Integrated Strategy for Analyzing the Unique Developmental Programs of Different Myoblast Subtypes pp. 1-12

Beatriz Estrada, Sung E Choe, Stephen S Gisselbrecht, Sebastien Michaud, Lakshmi Raj, Brian W Busser, Marc S Halfon, George M Church and Alan M Michelson