PLOS Genetics

2005 - 2022

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Volume 6, issue 12, 2010

Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation pp. 1-14

Gordan Lauc, Abdelkader Essafi, Jennifer E Huffman, Caroline Hayward, Ana Knežević, Jayesh J Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F Wilson, Alan F Wright, Nicholas D Hastie, Harry Campbell, Pauline M Rudd and Igor Rudan

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress pp. 1-9

Clement T Y Chan, Madhu Dyavaiah, Michael S DeMott, Koli Taghizadeh, Peter C Dedon and Thomas J Begley

A Unifying Framework for Evaluating the Predictive Power of Genetic Variants Based on the Level of Heritability Explained pp. 1-13

Hon-Cheong So and Pak C Sham

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice pp. 1-11

Linda Møllersen, Alexander D Rowe, Elisabeth Larsen, Torbjørn Rognes and Arne Klungland

Volume 6, issue 11, 2010

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A pp. 1-8

Carola Marzi, Eva Albrecht, Pirro G Hysi, Vasiliki Lagou, Melanie Waldenberger, Anke Tönjes, Inga Prokopenko, Katharina Heim, Hannah Blackburn, Janina S Ried, Marcus E Kleber, Massimo Mangino, Barbara Thorand, Annette Peters, Christopher J Hammond, Harald Grallert, Bernhard O Boehm, Peter Kovacs, Ludwig Geistlinger, Holger Prokisch, Bernhard R Winkelmann, Tim D Spector, H-Erich Wichmann, Michael Stumvoll, Nicole Soranzo, Winfried März, Wolfgang Koenig, Thomas Illig and Christian Gieger

An Evolutionary Framework for Association Testing in Resequencing Studies pp. 1-11

C Ryan King, Paul J Rathouz and Dan L Nicolae

Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone pp. 1-12

Lavinia Paternoster, Mattias Lorentzon, Liesbeth Vandenput, Magnus K Karlsson, Östen Ljunggren, Andreas Kindmark, Dan Mellstrom, John P Kemp, Caroline E Jarett, Jeff M P Holly, Adrian Sayers, Beate St. Pourcain, Nicholas J Timpson, Panos Deloukas, George Davey Smith, Susan M Ring, Martin Evans, Jon H Tobias and Claes Ohlsson

Volume 6, issue 10, 2010

A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions pp. 1-14

Dajiang J Liu and Suzanne M Leal

Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo pp. 1-12

M Kamran Ikram, Sim Xueling, Richard A Jensen, Mary Frances Cotch, Alex W Hewitt, M Arfan Ikram, Jie Jin Wang, Ronald Klein, Barbara E K Klein, Monique M B Breteler, Ning Cheung, Gerald Liew, Paul Mitchell, Andre G Uitterlinden, Fernando Rivadeneira, Albert Hofman, Paulus T V M de Jong, Cornelia M van Duijn, Linda Kao, Ching-Yu Cheng, Albert Vernon Smith, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Fridbert Jonasson, Gudny Eiriksdottir, Thor Aspelund, Global BPgen Consortium, Tamara B Harris, Lenore J Launer, Kent D Taylor, Xiaohui Li, Sudha K Iyengar, Quansheng Xi, Theru A Sivakumaran, David A Mackey, Stuart MacGregor, Nicholas G Martin, Terri L Young, Josh C Bis, Kerri L Wiggins, Susan R Heckbert, Christopher J Hammond, Toby Andrew, Samantha Fahy, John Attia, Elizabeth G Holliday, Rodney J Scott, F M Amirul Islam, Jerome I Rotter, Annie K McAuley, Eric Boerwinkle, E Shyong Tai, Vilmundur Gudnason, David S Siscovick, Johannes R Vingerling and Tien Y Wong

Characterising and Predicting Haploinsufficiency in the Human Genome pp. 1-11

Ni Huang, Insuk Lee, Edward M Marcotte and Matthew E Hurles

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension pp. 1-11

Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K Lee, Davide Gentilini, Claire E Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M C Connell, Morris Brown, Nilesh J Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H Erich Wichmann, Maris Laan, David P Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D Spector, Gavin Lucas, Sekar Kathiresan, David S Siscovick, Jian'an Luan, Ruth J F Loos, Nicholas J Wareham, Brenda W Penninx, Ilja M Nolte, Martin McBride, William H Miller, Stuart A Nicklin, Andrew H Baker, Delyth Graham, Robert A McDonald, Jill P Pell, Naveed Sattar, Paul Welsh, Global BPgen Consortium, Patricia Munroe, Mark J Caulfield, Alberto Zanchetti and Anna F Dominiczak

Volume 6, issue 9, 2010

The Potential for Enhancing the Power of Genetic Association Studies in African Americans through the Reuse of Existing Genotype Data pp. 1-13

Gary K Chen, Robert C Millikan, Esther M John, Christine B Ambrosone, Leslie Bernstein, Wei Zheng, Jennifer J Hu, Stephen J Chanock, Regina G Ziegler, Elisa V Bandera, Brian E Henderson, Christopher A Haiman and Daniel O Stram

Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study pp. 1-13

Sebastian Okser, Terho Lehtimäki, Laura L Elo, Nina Mononen, Nina Peltonen, Mika Kähönen, Markus Juonala, Yue-Mei Fan, Jussi A Hernesniemi, Tomi Laitinen, Leo-Pekka Lyytikäinen, Riikka Rontu, Carita Eklund, Nina Hutri-Kähönen, Leena Taittonen, Mikko Hurme, Jorma S A Viikari, Olli T Raitakari and Tero Aittokallio

Genetic Architecture of Complex Traits and Accuracy of Genomic Prediction: Coat Colour, Milk-Fat Percentage, and Type in Holstein Cattle as Contrasting Model Traits pp. 1-11

Ben J Hayes, Jennie Pryce, Amanda J Chamberlain, Phil J Bowman and Mike E Goddard

A Novel Statistic for Genome-Wide Interaction Analysis pp. 1-15

Xuesen Wu, Hua Dong, Li Luo, Yun Zhu, Gang Peng, John D Reveille and Momiao Xiong

Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function pp. 1-12

Soumya Raychaudhuri, Joshua M Korn, Steven A McCarroll, The International Schizophrenia Consortium, David Altshuler, Pamela Sklar, Shaun Purcell and Mark J Daly

Analysis of Population Structure: A Unifying Framework and Novel Methods Based on Sparse Factor Analysis pp. 1-12

Barbara E Engelhardt and Matthew Stephens

Volume 6, issue 8, 2010

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD pp. 1-16

Nancy L Saccone, Robert C Culverhouse, Tae-Hwi Schwantes-An, Dale S Cannon, Xiangning Chen, Sven Cichon, Ina Giegling, Shizhong Han, Younghun Han, Kaisu Keskitalo-Vuokko, Xiangyang Kong, Maria Teresa Landi, Jennie Z Ma, Susan E Short, Sarah H Stephens, Victoria L Stevens, Lingwei Sun, Yufei Wang, Angela S Wenzlaff, Steven H Aggen, Naomi Breslau, Peter Broderick, Nilanjan Chatterjee, Jingchun Chen, Andrew C Heath, Markku Heliövaara, Nicole R Hoft, David J Hunter, Majken K Jensen, Nicholas G Martin, Grant W Montgomery, Tianhua Niu, Thomas J Payne, Leena Peltonen, Michele L Pergadia, John P Rice, Richard Sherva, Margaret R Spitz, Juzhong Sun, Jen C Wang, Robert B Weiss, William Wheeler, Stephanie H Witt, Bao-Zhu Yang, Neil E Caporaso, Marissa A Ehringer, Tim Eisen, Susan M Gapstur, Joel Gelernter, Richard Houlston, Jaakko Kaprio, Kenneth S Kendler, Peter Kraft, Mark F Leppert, Ming D Li, Pamela A F Madden, Markus M Nöthen, Sreekumar Pillai, Marcella Rietschel, Dan Rujescu, Ann Schwartz, Christopher I Amos and Laura J Bierut

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits pp. 1-19

Ayellet V Segrè, Consortium Diagram, Investigators Magic, Leif Groop, Vamsi K Mootha, Mark J Daly and David Altshuler

Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels pp. 1-11

Tamra E Meyer, Germaine C Verwoert, Shih-Jen Hwang, Nicole L Glazer, Albert V Smith, Frank J A van Rooij, Georg B Ehret, Eric Boerwinkle, Janine F Felix, Tennille S Leak, Tamara B Harris, Qiong Yang, Abbas Dehghan, Thor Aspelund, Ronit Katz, Georg Homuth, Thomas Kocher, Rainer Rettig, Janina S Ried, Christian Gieger, Hanna Prucha, Arne Pfeufer, Thomas Meitinger, Josef Coresh, Albert Hofman, Mark J Sarnak, Yii- Der Ida Chen, André G Uitterlinden, Aravinda Chakravarti, Bruce M Psaty, Cornelia M van Duijn, W H Linda Kao, Jacqueline C M Witteman, Vilmundur Gudnason, David S Siscovick, Caroline S Fox, Anna Köttgen, The Genetic Factors for Osteoporosis (GEFOS) Consortium and Meta Analysis of Glucose and Insulin Related Traits Consortium (MAGIC)

Volume 6, issue 7, 2010

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation pp. 1-14

Paola Fabrizio, Shawn Hoon, Mehrnaz Shamalnasab, Abdulaye Galbani, Min Wei, Guri Giaever, Corey Nislow and Valter D Longo

Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot” pp. 1-10

Sharon E Johnatty, Jonathan Beesley, Xiaoqing Chen, Stuart Macgregor, David L Duffy, Amanda B Spurdle, Anna deFazio, Natalie Gava, Penelope M Webb, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Mary Anne Rossing, Jennifer Anne Doherty, Marc T Goodman, Galina Lurie, Pamela J Thompson, Lynne R Wilkens, Roberta B Ness, Kirsten B Moysich, Jenny Chang-Claude, Shan Wang-Gohrke, Daniel W Cramer, Kathryn L Terry, Susan E Hankinson, Shelley S Tworoger, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Stephen J Chanock, Paul D Pharoah, Honglin Song, Alice S Whitemore, Celeste L Pearce, Daniel O Stram, Anna H Wu, Malcolm C Pike, Simon A Gayther, Susan J Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Hoda Anton-Culver, Argyrios Ziogas, Estrid Hogdall, Susanne K Kjaer, Claus Hogdall, Andrew Berchuck, Joellen M Schildkraut, Edwin S Iversen, Patricia G Moorman, Catherine M Phelan, Thomas A Sellers, Julie M Cunningham, Robert A Vierkant, David N Rider, Ellen L Goode, Izhak Haviv, Georgia Chenevix-Trench and Ovarian Cancer Association Consortium

Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene pp. 1-12

Karen Kapur, Toby Johnson, Noam D Beckmann, Joban Sehmi, Toshiko Tanaka, Zoltán Kutalik, Unnur Styrkarsdottir, Weihua Zhang, Diana Marek, Daniel F Gudbjartsson, Yuri Milaneschi, Hilma Holm, Angelo DiIorio, Dawn Waterworth, Yun Li, Andrew B Singleton, Unnur S Bjornsdottir, Gunnar Sigurdsson, Dena G Hernandez, Ranil DeSilva, Paul Elliott, Gudmundur I Eyjolfsson, Jack M Guralnik, James Scott, Unnur Thorsteinsdottir, Stefania Bandinelli, John Chambers, Kari Stefansson, Gérard Waeber, Luigi Ferrucci, Jaspal S Kooner, Vincent Mooser, Peter Vollenweider, Jacques S Beckmann, Murielle Bochud and Sven Bergmann

Question and Answer: An Anniversary Interview with Jane Gitschier pp. 1-2

Jane Gitschier

Volume 6, issue 6, 2010

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study pp. 1-10

Guillaume Paré, Nancy R Cook, Paul M Ridker and Daniel I Chasman

An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits pp. 1-16

Yi-Hsiang Hsu, M Carola Zillikens, Scott G Wilson, Charles R Farber, Serkalem Demissie, Nicole Soranzo, Estelle N Bianchi, Elin Grundberg, Liming Liang, J Brent Richards, Karol Estrada, Yanhua Zhou, Atila van Nas, Miriam F Moffatt, Guangju Zhai, Albert Hofman, Joyce B van Meurs, Huibert A P Pols, Roger I Price, Olle Nilsson, Tomi Pastinen, L Adrienne Cupples, Aldons J Lusis, Eric E Schadt, Serge Ferrari, André G Uitterlinden, Fernando Rivadeneira, Timothy D Spector, David Karasik and Douglas P Kiel

A Genome-Wide Association Study of Optic Disc Parameters pp. 1-12

Wishal D Ramdas, Leonieke M E van Koolwijk, M Kamran Ikram, Nomdo M Jansonius, Paulus T V M de Jong, Arthur A B Bergen, Aaron Isaacs, Najaf Amin, Yurii S Aulchenko, Roger C W Wolfs, Albert Hofman, Fernando Rivadeneira, Ben A Oostra, Andre G Uitterlinden, Pirro Hysi, Christopher J Hammond, Hans G Lemij, Johannes R Vingerling, Caroline C W Klaver and Cornelia M van Duijn

Consent and Internet-Enabled Human Genomics pp. 1-3

Greg Gibson and Gregory P Copenhaver

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits pp. 1-20

Nicholas Eriksson, J Michael Macpherson, Joyce Y Tung, Lawrence S Hon, Brian Naughton, Serge Saxonov, Linda Avey, Anne Wojcicki, Itsik Pe'er and Joanna Mountain

Volume 6, issue 5, 2010

Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness pp. 1-10

Yi Lu, David P Dimasi, Pirro G Hysi, Alex W Hewitt, Kathryn P Burdon, Tze'Yo Toh, Jonathan B Ruddle, Yi Ju Li, Paul Mitchell, Paul R Healey, Grant W Montgomery, Narelle Hansell, Timothy D Spector, Nicholas G Martin, Terri L Young, Christopher J Hammond, Stuart Macgregor, Jamie E Craig and David A Mackey

Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci pp. 1-15

Fan Liu, Andreas Wollstein, Pirro G Hysi, Georgina A Ankra-Badu, Timothy D Spector, Daniel Park, Gu Zhu, Mats Larsson, David L Duffy, Grant W Montgomery, David A Mackey, Susan Walsh, Oscar Lao, Albert Hofman, Fernando Rivadeneira, Johannes R Vingerling, André G Uitterlinden, Nicholas G Martin, Christopher J Hammond and Manfred Kayser

GC-Biased Evolution Near Human Accelerated Regions pp. 1-13

Sol Katzman, Andrew D Kern, Katherine S Pollard, Sofie R Salama and David Haussler

Volume 6, issue 4, 2010

Fragilities Caused by Dosage Imbalance in Regulation of the Budding Yeast Cell Cycle pp. 1-12

Kazunari Kaizu, Hisao Moriya and Hiroaki Kitano

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups pp. 1-10

André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, Carla I G Vogel, Timo D Müller, Harald Grallert, H-Erich Wichmann, Beverley Balkau, Barbara Heude, Marjo-Riitta Jarvelin, Anna-Liisa Hartikainen, Claire Levy-Marchal, Jacques Weill, Jérôme Delplanque, Antje Körner, Wieland Kiess, Peter Kovacs, Nigel W Rayner, Inga Prokopenko, Mark I McCarthy, Helmut Schäfer, Ivonne Jarick, Heiner Boeing, Eva Fisher, Thomas Reinehr, Joachim Heinrich, Peter Rzehak, Dietrich Berdel, Michael Borte, Heike Biebermann, Heiko Krude, Dieter Rosskopf, Christian Rimmbach, Winfried Rief, Tobias Fromme, Martin Klingenspor, Annette Schürmann, Nadja Schulz, Markus M Nöthen, Thomas W Mühleisen, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Tanja Boes, Thomas Illig, Philippe Froguel, Johannes Hebebrand and David Meyre

Volume 6, issue 3, 2010

Human Population Differentiation Is Strongly Correlated with Local Recombination Rate pp. 1-12

Alon Keinan and David Reich

Volume 6, issue 2, 2010

A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes pp. 1-9

Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I Freedman, Meredith A Bostrom, Jessica N Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P K Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W Bowden, Oluf Pedersen and Yusuke Nakamura

Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy pp. 1-7

Demetris Pillas, Clive J Hoggart, Martin Evans, Paul F O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna-Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J Timpson, Susan M Ring, Guohong Deng, Weihua Zhang, Mark I McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J M Coin, George Davey Smith and Marjo-Riitta Jarvelin

Volume 6, issue 1, 2010

Genetic Crossovers Are Predicted Accurately by the Computed Human Recombination Map pp. 1-11

Pavel P Khil and R Daniel Camerini-Otero

Volume 5, issue 12, 2009

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels pp. 1-10

J Brent Richards, Dawn Waterworth, Stephen O'Rahilly, Marie-France Hivert, Ruth J F Loos, John R B Perry, Toshiko Tanaka, Nicholas John Timpson, Robert K Semple, Nicole Soranzo, Kijoung Song, Nuno Rocha, Elin Grundberg, Josée Dupuis, Jose C Florez, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Robert Sladek, Yurii Aulchenko, David Evans, Gerard Waeber, Jeanette Erdmann, Mary-Susan Burnett, Naveed Sattar, Joseph Devaney, Christina Willenborg, Aroon Hingorani, Jaquelin C M Witteman, Peter Vollenweider, Beate Glaser, Christian Hengstenberg, Luigi Ferrucci, David Melzer, Klaus Stark, John Deanfield, Janina Winogradow, Martina Grassl, Alistair S Hall, Josephine M Egan, John R Thompson, Sally L Ricketts, Inke R König, Wibke Reinhard, Scott Grundy, H-Erich Wichmann, Phil Barter, Robert Mahley, Y Antero Kesaniemi, Daniel J Rader, Muredach P Reilly, Stephen E Epstein, Alexandre F R Stewart, Cornelia M Van Duijn, Heribert Schunkert, Keith Burling, Panos Deloukas, Tomi Pastinen, Nilesh J Samani, Ruth McPherson, George Davey Smith, Timothy M Frayling, Nicholas J Wareham, James B Meigs, Vincent Mooser, Tim D Spector and Consortium Giant

Volume 5, issue 11, 2009

On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies pp. 1-9

Sungho Won, Jemma B Wilk, Rasika A Mathias, Christopher J O'Donnell, Edwin K Silverman, Kathleen Barnes, George T O'Connor, Scott T Weiss and Christoph Lange

Volume 5, issue 10, 2009

A Genealogical Interpretation of Principal Components Analysis pp. 1-10

Gil McVean

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? pp. 1-10

Iris M Heid, Cornelia Huth, Ruth J F Loos, Florian Kronenberg, Vera Adamkova, Sonia S Anand, Kristin Ardlie, Heike Biebermann, Peter Bjerregaard, Heiner Boeing, Claude Bouchard, Marina Ciullo, Jackie A Cooper, Dolores Corella, Christian Dina, James C Engert, Eva Fisher, Francesc Francès, Philippe Froguel, Johannes Hebebrand, Robert A Hegele, Anke Hinney, Margret R Hoehe, Frank B Hu, Jaroslav A Hubacek, Steve E Humphries, Steven C Hunt, Thomas Illig, Marjo-Riita Järvelin, Marika Kaakinen, Barbara Kollerits, Heiko Krude, Jitender Kumar, Leslie A Lange, Birgit Langer, Shengxu Li, Andreas Luchner, Helen N Lyon, David Meyre, Karen L Mohlke, Vincent Mooser, Almut Nebel, Thuy Trang Nguyen, Bernhard Paulweber, Louis Perusse, Lu Qi, Tuomo Rankinen, Dieter Rosskopf, Stefan Schreiber, Shantanu Sengupta, Rossella Sorice, Anita Suk, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Henry Völzke, Karani S Vimaleswaran, Nicholas J Wareham, Dawn Waterworth, Salim Yusuf, Cecilia Lindgren, Mark I McCarthy, Christoph Lange, Joel N Hirschhorn, Nan Laird and H-Erich Wichmann

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes pp. 1-11

Zhi Wei, Kai Wang, Hui-Qi Qu, Haitao Zhang, Jonathan Bradfield, Cecilia Kim, Edward Frackleton, Cuiping Hou, Joseph T Glessner, Rosetta Chiavacci, Charles Stanley, Dimitri Monos, Struan F A Grant, Constantin Polychronakos and Hakon Hakonarson

Inferring the Joint Demographic History of Multiple Populations from Multidimensional SNP Frequency Data pp. 1-11

Ryan N Gutenkunst, Ryan D Hernandez, Scott H Williamson and Carlos D Bustamante

Needles in the Haystack: Identifying Individuals Present in Pooled Genomic Data pp. 1-8

Rosemary Braun, William Rowe, Carl Schaefer, Jinghui Zhang and Kenneth Buetow

The Limits of Individual Identification from Sample Allele Frequencies: Theory and Statistical Analysis pp. 1-6

Peter M Visscher and William G Hill

Volume 5, issue 9, 2009

A Genome-Wide Association Analysis Identified a Novel Susceptible Locus for Pathological Myopia at 11q24.1 pp. 1-7

Hideo Nakanishi, Ryo Yamada, Norimoto Gotoh, Hisako Hayashi, Kenji Yamashiro, Noriaki Shimada, Kyoko Ohno-Matsui, Manabu Mochizuki, Masaaki Saito, Tomohiro Iida, Keitaro Matsuo, Kazuo Tajima, Nagahisa Yoshimura and Fumihiko Matsuda

Volume 5, issue 8, 2009

Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children pp. 1-11

Dana B Hancock, Isabelle Romieu, Min Shi, Juan-Jose Sienra-Monge, Hao Wu, Grace Y Chiu, Huiling Li, Blanca Estela del Rio-Navarro, Saffron A G Willis-Owens, Scott T Weiss, Benjamin A Raby, Hong Gao, Celeste Eng, Rocio Chapela, Esteban G Burchard, Hua Tang, Patrick F Sullivan and Stephanie J London

Volume 5, issue 7, 2009

EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans pp. 1-19

Gyungah Jun, Hong Guo, Barbara E K Klein, Ronald Klein, Jie Jin Wang, Paul Mitchell, Hui Miao, Kristine E Lee, Tripti Joshi, Matthias Buck, Preeti Chugha, David Bardenstein, Alison P Klein, Joan E Bailey-Wilson, Xiaohua Gong, Tim D Spector, Toby Andrew, Christopher J Hammond, Robert C Elston, Sudha K Iyengar and Bingcheng Wang

On Quality Control Measures in Genome-Wide Association Studies: A Test to Assess the Genotyping Quality of Individual Probands in Family-Based Association Studies and an Application to the HapMap Data pp. 1-11

David W Fardo, Iuliana Ionita-Laza and Christoph Lange

Scientists←Editors←Scientists: The Past, Present, and Future of PLoS Genetics pp. 1-2

Gregory S Barsh and Gregory P Copenhaver

The Ups and Downs of Mutation Frequencies during Aging Can Account for the Apert Syndrome Paternal Age Effect pp. 1-9

Song-Ro Yoon, Jian Qin, Rivka L Glaser, Ethylin Wang Jabs, Nancy S Wexler, Rebecca Sokol, Norman Arnheim and Peter Calabrese

Enhanced Disease Susceptibility 1 and Salicylic Acid Act Redundantly to Regulate Resistance Gene-Mediated Signaling pp. 1-18

Srivathsa C Venugopal, Rae-Dong Jeong, Mihir K Mandal, Shifeng Zhu, A C Chandra-Shekara, Ye Xia, Matthew Hersh, Arnold J Stromberg, DuRoy Navarre, Aardra Kachroo and Pradeep Kachroo

Statistical Power of Model Selection Strategies for Genome-Wide Association Studies pp. 1-14

Zheyang Wu and Hongyu Zhao

Volume 5, issue 6, 2009

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations pp. 1-10

Melanie Kolz, Toby Johnson, Serena Sanna, Alexander Teumer, Veronique Vitart, Markus Perola, Massimo Mangino, Eva Albrecht, Chris Wallace, Martin Farrall, Åsa Johansson, Dale R Nyholt, Yurii Aulchenko, Jacques S Beckmann, Sven Bergmann, Murielle Bochud, Morris Brown, Harry Campbell, for the EUROSPAN Consortium, John Connell, Anna Dominiczak, Georg Homuth, Claudia Lamina, Mark I McCarthy, for the ENGAGE Consortium, Thomas Meitinger, Vincent Mooser, Patricia Munroe, Matthias Nauck, John Peden, Holger Prokisch, Perttu Salo, Veikko Salomaa, Nilesh J Samani, David Schlessinger, Manuela Uda, Uwe Völker, Gérard Waeber, Dawn Waterworth, Rui Wang-Sattler, Alan F Wright, Jerzy Adamski, John B Whitfield, Ulf Gyllensten, James F Wilson, Igor Rudan, Peter Pramstaller, Hugh Watkins, for the PROCARDIS Consortium, Angela Doering, H-Erich Wichmann, for the KORA Study, Tim D Spector, Leena Peltonen, Henry Völzke, Ramaiah Nagaraja, Peter Vollenweider, Mark Caulfield, For The Wtccc, Thomas Illig and Christian Gieger

The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland pp. 1-10

Alkes L Price, Agnar Helgason, Snaebjorn Palsson, Hreinn Stefansson, David St. Clair, Ole A Andreassen, David Reich, Augustine Kong and Kari Stefansson

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium pp. 1-9

Nancy L Heard-Costa, M Carola Zillikens, Keri L Monda, Åsa Johansson, Tamara B Harris, Mao Fu, Talin Haritunians, Mary F Feitosa, Thor Aspelund, Gudny Eiriksdottir, Melissa Garcia, Lenore J Launer, Albert V Smith, Braxton D Mitchell, Patrick F McArdle, Alan R Shuldiner, Suzette J Bielinski, Eric Boerwinkle, Fred Brancati, Ellen W Demerath, James S Pankow, Alice M Arnold, Yii- Der Ida Chen, Nicole L Glazer, Barbara McKnight, Bruce M Psaty, Jerome I Rotter, Najaf Amin, Harry Campbell, Ulf Gyllensten, Cristian Pattaro, Peter P Pramstaller, Igor Rudan, Maksim Struchalin, Veronique Vitart, Xiaoyi Gao, Aldi Kraja, Michael A Province, Qunyuan Zhang, Larry D Atwood, Josée Dupuis, Joel N Hirschhorn, Cashell E Jaquish, Christopher J O'Donnell, Ramachandran S Vasan, Charles C White, Yurii S Aulchenko, Karol Estrada, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Jacqueline C M Witteman, Ben A Oostra, Robert C Kaplan, Vilmundur Gudnason, Jeffrey R O'Connell, Ingrid B Borecki, Cornelia M van Duijn, L Adrienne Cupples, Caroline S Fox and Kari E North

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution pp. 1-13

Cecilia M Lindgren, Iris M Heid, Joshua C Randall, Claudia Lamina, Valgerdur Steinthorsdottir, Lu Qi, Elizabeth K Speliotes, Gudmar Thorleifsson, Cristen J Willer, Blanca M Herrera, Anne U Jackson, Noha Lim, Paul Scheet, Nicole Soranzo, Najaf Amin, Yurii S Aulchenko, John C Chambers, Alexander Drong, Jian'an Luan, Helen N Lyon, Fernando Rivadeneira, Serena Sanna, Nicholas J Timpson, M Carola Zillikens, Jing Hua Zhao, Peter Almgren, Stefania Bandinelli, Amanda J Bennett, Richard N Bergman, Lori L Bonnycastle, Suzannah J Bumpstead, Stephen J Chanock, Lynn Cherkas, Peter Chines, Lachlan Coin, Cyrus Cooper, Gabriel Crawford, Angela Doering, Anna Dominiczak, Alex S F Doney, Shah Ebrahim, Paul Elliott, Michael R Erdos, Karol Estrada, Luigi Ferrucci, Guido Fischer, Nita G Forouhi, Christian Gieger, Harald Grallert, Christopher J Groves, Scott Grundy, Candace Guiducci, David Hadley, Anders Hamsten, Aki S Havulinna, Albert Hofman, Rolf Holle, John W Holloway, Thomas Illig, Bo Isomaa, Leonie C Jacobs, Karen Jameson, Pekka Jousilahti, Fredrik Karpe, Johanna Kuusisto, Jaana Laitinen, G Mark Lathrop, Debbie A Lawlor, Massimo Mangino, Wendy L McArdle, Thomas Meitinger, Mario A Morken, Andrew P Morris, Patricia Munroe, Narisu Narisu, Anna Nordström, Peter Nordström, Ben A Oostra, Colin N A Palmer, Felicity Payne, John F Peden, Inga Prokopenko, Frida Renström, Aimo Ruokonen, Veikko Salomaa, Manjinder S Sandhu, Laura J Scott, Angelo Scuteri, Kaisa Silander, Kijoung Song, Xin Yuan, Heather M Stringham, Amy J Swift, Tiinamaija Tuomi, Manuela Uda, Peter Vollenweider, Gerard Waeber, Chris Wallace, G Bragi Walters, Michael N Weedon, The Wellcome Trust Case Control Consortium, Jacqueline C M Witteman, Cuilin Zhang, Weihua Zhang, Mark J Caulfield, Francis S Collins, George Davey Smith, Ian N M Day, Paul W Franks, Andrew T Hattersley, Frank B Hu, Marjo-Riitta Jarvelin, Augustine Kong, Jaspal S Kooner, Markku Laakso, Edward Lakatta, Vincent Mooser, Andrew D Morris, Leena Peltonen, Nilesh J Samani, Timothy D Spector, David P Strachan, Toshiko Tanaka, Jaakko Tuomilehto, André G Uitterlinden, Cornelia M van Duijn, Nicholas J Wareham, Hugh Watkins for the PROCARDIS Consortia, Dawn M Waterworth, Michael Boehnke, Panos Deloukas, Leif Groop, David J Hunter, Unnur Thorsteinsdottir, David Schlessinger, H-Erich Wichmann, Timothy M Frayling, Gonçalo R Abecasis, Joel N Hirschhorn, Ruth J F Loos, Kari Stefansson, Karen L Mohlke, Inês Barroso and Mark I McCarthy for the GIANT Consortium

Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations pp. 1-18

Alkes L Price, Arti Tandon, Nick Patterson, Kathleen C Barnes, Nicholas Rafaels, Ingo Ruczinski, Terri H Beaty, Rasika Mathias, David Reich and Simon Myers

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies pp. 1-15

Bryan N Howie, Peter Donnelly and Jonathan Marchini

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions pp. 1-15

Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler and Mark J Daly

Volume 5, issue 5, 2009

Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip pp. 1-13

Chris C A Spencer, Zhan Su, Peter Donnelly and Jonathan Marchini

Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference pp. 1-13

Eric A Stone and Julien F Ayroles

Epistatic Module Detection for Case-Control Studies: A Bayesian Model with a Gibbs Sampling Strategy pp. 1-18

Wanwan Tang, Xuebing Wu, Rui Jiang and Yanda Li

Evaluation of Haplotype Inference Using Definitive Haplotype Data Obtained from Complete Hydatidiform Moles, and Its Significance for the Analyses of Positively Selected Regions pp. 1-10

Koichiro Higasa, Yoji Kukita, Kiyoko Kato, Norio Wake, Tomoko Tahira and Kenshi Hayashi

Discovery of Rare Variants via Sequencing: Implications for the Design of Complex Trait Association Studies pp. 1-9

Bingshan Li and Suzanne M Leal

Volume 5, issue 4, 2009

Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size pp. 1-13

Nicole Soranzo, Fernando Rivadeneira, Usha Chinappen-Horsley, Ida Malkina, J Brent Richards, Naomi Hammond, Lisette Stolk, Alexandra Nica, Michael Inouye, Albert Hofman, Jonathan Stephens, Eleanor Wheeler, Pascal Arp, Rhian Gwilliam, P Mila Jhamai, Simon Potter, Amy Chaney, Mohammed J R Ghori, Radhi Ravindrarajah, Sergey Ermakov, Karol Estrada, Huibert A P Pols, Frances M Williams, Wendy L McArdle, Joyce B van Meurs, Ruth J F Loos, Emmanouil T Dermitzakis, Kourosh R Ahmadi, Deborah J Hart, Willem H Ouwehand, Nicholas J Wareham, Inês Barroso, Manjinder S Sandhu, David P Strachan, Gregory Livshits, Timothy D Spector, André G Uitterlinden and Panos Deloukas

Inferring the Demographic History of African Farmers and Pygmy Hunter–Gatherers Using a Multilocus Resequencing Data Set pp. 1-13

Etienne Patin, Guillaume Laval, Luis B Barreiro, Antonio Salas, Ornella Semino, Silvana Santachiara-Benerecetti, Kenneth K Kidd, Judith R Kidd, Lolke Van der Veen, Jean-Marie Hombert, Antoine Gessain, Alain Froment, Serge Bahuchet, Evelyne Heyer and Lluís Quintana-Murci

Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers pp. 1-13

Buhm Han, Hyun Min Kang and Eleazar Eskin

Volume 5, issue 3, 2009

The Distribution of Fitness Effects of Beneficial Mutations in Pseudomonas aeruginosa pp. 1-7

R Craig MacLean and Angus Buckling

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics pp. 1-7

Michael A Nalls, Javier Simon-Sanchez, J Raphael Gibbs, Coro Paisan-Ruiz, Jose Tomas Bras, Toshiko Tanaka, Mar Matarin, Sonja Scholz, Charles Weitz, Tamara B Harris, Luigi Ferrucci, John Hardy and Andrew B Singleton

Rapid Pathway Evolution Facilitated by Horizontal Gene Transfers across Prokaryotic Lineages pp. 1-8

Wataru Iwasaki and Toshihisa Takagi

Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966 pp. 1-8

Ulla Sovio, Amanda J Bennett, Iona Y Millwood, John Molitor, Paul F O'Reilly, Nicholas J Timpson, Marika Kaakinen, Jaana Laitinen, Jari Haukka, Demetris Pillas, Ioanna Tzoulaki, Jassy Molitor, Clive Hoggart, Lachlan J M Coin, John Whittaker, Anneli Pouta, Anna-Liisa Hartikainen, Nelson B Freimer, Elisabeth Widen, Leena Peltonen, Paul Elliott, Mark I McCarthy and Marjo-Riitta Jarvelin

A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose pp. 1-9

Fumihiko Takeuchi, Ralph McGinnis, Stephane Bourgeois, Chris Barnes, Niclas Eriksson, Nicole Soranzo, Pamela Whittaker, Venkatesh Ranganath, Vasudev Kumanduri, William McLaren, Lennart Holm, Jonatan Lindh, Anders Rane, Mia Wadelius and Panos Deloukas

Volume 5, issue 2, 2009

A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic pp. 1-11

Bo Eskerod Madsen and Sharon R Browning

Volume 5, issue 1, 2009

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production pp. 1-8

Lisa M Maier, Christopher E Lowe, Jason Cooper, Kate Downes, David E Anderson, Christopher Severson, Pamela M Clark, Brian Healy, Neil Walker, Cristin Aubin, Jorge R Oksenberg, Stephen L Hauser, Alistair Compston, Stephen Sawcer, The International Multiple Sclerosis Genetics Consortium, Philip L De Jager, Linda S Wicker, John A Todd and David A Hafler

Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study pp. 1-11

Rahul C Deo, David Reich, Arti Tandon, Ermeg Akylbekova, Nick Patterson, Alicja Waliszewska, Sekar Kathiresan, Daniel Sarpong, Herman A Taylor and James G Wilson